Smartphone-based application for training outpatient cardiac rehabilitation: Design and usability evaluation

Erfan Saatchian; Sina Ehsani; Alireza Montazerabadi

doi:10.5812/koomesh-154041

Koomesh

Journal of Semnan University of Medical Sciences

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Smartphone-based application for training outpatient cardiac rehabilitation: Design and usability evaluation

Author(s):

Erfan Saatchian^{1, 2},

Sina Ehsani^{2, 3},

Alireza Montazerabadi^{3, 4,*}

1Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

2Dept. of Medical Physics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3- Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

4- Dept. of Medical Physics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Koomesh:Vol. 22, issue 4; e154041

Published online:Dec 24, 2020

Article type:Research Article

How to Cite:Erfan SaatchianSina EhsaniAlireza MontazerabadiSmartphone-based application for training outpatient cardiac rehabilitation: Design and usability evaluation.koomesh.22(4):e154041.

Abstract

Introduction: Alzheimer’s disease (AD) is the most common cause of dementia worldwide. Mild cognitive impairment (MCI) is often the prodromal stage to AD. Most patients with MCI harbor the pathologic changes of AD and demonstrate transition to AD at a rate of 10–15% per year. Accumulating evidence indicates that the asymmetry changes of left and right brain have happened in the early stage of AD. However, the features of asymmetry changes in anterior cingulate cortex (ACC) is still unclear. Materials and Methods: We examined the left-right asymmetry changes of metabolites in ACC. In this account, 14 cases of mild AD patients meeting criteria for probable AD of NINDS-ADRDA, 12 cases of MCI according to the Mayo Clinic Alzheimer’s Disease Research Center criteria, and 15 cases of age-matched normal controls (NC) received Proton magnetic resonance spectroscopy (1H-MRS) for measurement of NAA/mI, NAA/Cr, Cho/Cr, and mI/Cr ratios in the ACC bilaterally. We analyzed MRS data by paired t-test to validate the left-right asymmetry of MRS data in the ACC. Results: In AD, there was a significant difference in mI/Cr between the left and right ACC (P

Keywords

Magnetic Resonance Spectroscopy

Alzheimer Disease

Cognitive Dysfunction

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