Effect of intranasal midazolam with/without inhalation sedation (N2O/O2) in 3‒6-year-old uncooperative dental patients

Nahid Askarizadeh; Fereshteh Dehghan; Yasaman Rezvani; Leila Eftekhar; Seyed Mohammad Mireskandari; Mona Naghibi

doi:10.5812/koomesh-154105

Koomesh

Journal of Semnan University of Medical Sciences

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Effect of intranasal midazolam with/without inhalation sedation (N2O/O2) in 3‒6-year-old uncooperative dental patients

Author(s):

Nahid Askarizadeh¹,

Fereshteh Dehghan²,

Yasaman Rezvani^3,*,

Leila Eftekhar

⁴,

Seyed Mohammad Mireskandari⁵,

Mona Naghibi⁶

1Depat. of Pediatric Dentistry, Dental School, Azad University of Medical Sciences, Tehran, Iran

2Tehran, Iran

3Depat. of Pediatric Dentistry, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4Depat. of Pediatric Dentistry, Dental School, Alborz University of Medical Sciences, Karaj, Iran

5- Anesthesiology department, Tehran University of medical sciences, Tehran, Iran

6- Tehran, Iran

Koomesh:Vol. 24, issue 5; e154105

Published online:Sep 24, 2022

Article type:Research Article

How to Cite:Nahid AskarizadehFereshteh DehghanYasaman RezvaniLeila EftekharSeyed Mohammad MireskandariMona Naghibiet al.Effect of intranasal midazolam with/without inhalation sedation (N2O/O2) in 3‒6-year-old uncooperative dental patients.koomesh.24(5):e154105.

Abstract

Introduction: Due to incomplete development of coping skills in children, they usually cannot cope with stressful situations like dental appointments. The present study aims to evaluate the effect of intranasal midazolam with/without inhalation sedation (N2O/O2) in children with high levels of dental anxiety.
Materials and Methods: This crossover double-blinded clinical trial was conducted on 14 uncooperative children aged 3‒6, who required at least two similar dental treatment visits. Children were randomly sedated by the combination of intranasal midazolam (0.5 mg/kg) and nasal drops of lidocaine hydrochloride (2%) with or without inhalation sedation (N2O/O2) during each visit. Houpt’s scale for sedation was used to evaluate the patient`s behavior and efficacy of the sedation by an independent pediatric dentist.
Results: The combination of midazolam and inhalation sedation was significantly more effective in overall behavior after 15 minutes and at the end of the treatment (P<0.05), but not at the time of onset and discharge (P>0.05).
Conclusion: To manage the behavior of the children with high levels of dental anxiety, the combination of inhalation sedation with intranasal midazolam can be efficiently used.

Keywords

Anxiety

Conscious Sedation

Intranasal Drug administration

Nitrous Oxide

Midazolam

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