Abstract
Materials and Methods: Male rat infants received 5.27 g / kg milk powder soluble ethanol on days 2-10 after birth by gavage. They also received 10 and 20 mg/kg of simvastatin on days 2-10 after birth subcutaneously. Cognitive memory abnormalities were assessed 36 days after birth by the new object detection and then, the number of necrotic cells was assessed by nissl staining.
Results: Behavioral data showed that in the groups treated with simvastatin, the new object recognition memory increased compared to the ethanol group (P<0.01). In addition, in the ethanol group, an increase in cell death was observed in the CA1 region of the hippocampus, and treatment with simvastatin showed a significant decrease in the number of necrotic cells (P<0.01).
Conclusion: This study showed that simvastatin has a protective effect on alcohol-related neurological defects, although more research is needed in the future.