Pulmonary Arterial Hypertension

H Mortezaeian

Multidisciplinary Cardiovascular Annals

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Pulmonary Arterial Hypertension

Author(s):

H Mortezaeian^1,*

1Iran

Multidisciplinary Cardiovascular Annals:Vol. 1, issue 4; e8682

Published online:May 27, 2007

Article type:Research Article

Received:Sep 08, 2016

Accepted:May 27, 2007

How to Cite:Mortezaeian H. Pulmonary Arterial Hypertension. Multidiscip Cardio Annal. 2007;1(4):e8682. doi:

Abstract

Pulmonary hypertension is usually
classified as primary (idiopathic) or
secondary.1 It is now clear, however, that
there are conditions within the category of
secondary pulmonary hypertension that
resemble primary pulmonary hypertension
in their histopathological features and their
response to treatment. For this reason,
the World Health Organization (WHO)
classified pulmonary hypertension into
five groups on the basis of mechanisms,
rather than associated conditions.
In 2003, the World Health Organization
revised the classification of PAH into
5 categories based in part on etiology:
pulmonary arterial hypertension, pulmonary
venous hypertension, pulmonary
hypertension associated with hypoxemia,
pulmonary hypertension resulting from
chronic thrombotic or embolic disease,
and miscellaneous. 2 Group I of the WHO
classification, designated pulmonary
arterial hypertension, is the principal focus
of this review.
Pulmonary arterial hypertension is
defined as a sustained elevation of
pulmonary arterial pressure to more
than 25 mm Hg at rest or to more than
30 mm Hg with exercise, with a mean
pulmonary-capillary wedge pressure and
left ventricular end-diastolic pressure of
less than 15 mm Hg.3Diagnosis of PPH
one must excludes all secondary cause of
PHT and demonstrate normal pulmonary
wedge pressure. 2,3
Pathophysiology:
The histopathology of pulmonary vascular
disease has been classified in two phases,
early description in the 1950s (the Heath-
Edwards classification) and an extension
of this by Rabinovitch et al. 2.3Although pulmonary vascular resistance(
PVR = mPAP _ mPCWP/Q p) may be as
high as 8-10 Wood units immediately after
birth, it normally falls rapidly through
the first week of life. By 6-8 weeks,
pulmonary vascular resistance usually
has reached a normal adult level of 1-3
Wood units. In an infant, although the
pulmonary pressure is at systemic levels,
the pulmonary vascular resistance is low
and there is pulmonary over circulation.
2.3,23,26,28
Frequency data are difficult to confirm,
as there are no international registries
tracking the incidence and prevalence
of pulmonary hypertension. Elevated
pulmonary artery pressure in congenital
heart disease is caused by pulmonary over
circulation, pulmonary vasoconstriction,
and pulmonary vascular disease, either
alone or in combination.

Keywords

Hypertension

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References

1.
full Text available is pdf.

Pulmonary Thromboendarterectomy

gholamreza OMRANI,

Naser Jalilifar

OMRANI G, Jalilifar N. Pulmonary Thromboendarterectomy. Multidiscip Cardio Annal. 2009;2(4):e8727. doi:

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Jul

2023

Clinical and Paraclinical Findings of Primary Pulmonary Hypertension in Children

Hassan Mottaghi Moghaddam Shahri,

Mahboubeh Ghofrani,

Behzad Alizadeh,

Javad Seyedi,

Elahe Heidari

Mottaghi Moghaddam Shahri H, Ghofrani M, Alizadeh B, Seyedi J, Heidari E. Clinical and Paraclinical Findings of Primary Pulmonary Hypertension in Children. Multidiscip Cardio Annal. 2023;14(1):e114419. doi: https://doi.org/10.5812/mca-114419

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Jun

2012

Platelets in Pulmonary Hypertension: a Causative Role or a Simple Association?

Keyhan Sayadpour Zanjani

Sayadpour Zanjani K. Platelets in Pulmonary Hypertension: a Causative Role or a Simple Association?. Inn J Pediatr. 2015;22(2):. doi:

18

Aug

2011

Pulmonary Artery Banding in the Current Era: Is It Safe and Useful Yet?

Maziar Gholampour Dehaki

Gholampour Dehaki M. Pulmonary Artery Banding in the Current Era: Is It Safe and Useful Yet?. Multidiscip Cardio Annal. 2011;3(3):e8751. doi:

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2005

Comparison between echocardiography finding and cardiac catheterization data in diagnosis of pulmonary hypertension

NM Noori,

M Meraji

Noori N, Meraji M. Comparison between echocardiography finding and cardiac catheterization data in diagnosis of pulmonary hypertension. Zahedan J Res Med Sci. 2005;7(4):e94923. doi:

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Pulmonary Arterial Hypertension

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