Estimating Glomerular Filtration Rate in Overweight and Obese Malaysian Subjects

Nor Shaharudin; Abdul Abdul Gafor; Soehardy Zainudin; Norella Kong; Aini Aziz; Shamsul Shah

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Estimating Glomerular Filtration Rate in Overweight and Obese Malaysian Subjects

Author(s):

Nor Hayati Shaharudin¹,

Abdul Halim Abdul Gafor^2,*,

Soehardy Zainudin¹,

Norella CT Kong¹,

Aini Abdul Aziz¹,

Shamsul Azhar Shah¹

1Nephrology Unit, Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Lumpur, Malaysia

2Nephrology Unit, Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, halimgafor@gmail.com, Lumpur, Malaysia

Nephro-Urology Monthly:Vol. 3, issue 1; 15-22

Article type:Research Article

Received:Feb 23, 2010

Accepted:Mar 15, 2010

How to Cite:Nor Hayati ShaharudinAbdul Halim Abdul GaforSoehardy ZainudinNorella CT KongAini Abdul AzizShamsul Azhar Shahet al.Estimating Glomerular Filtration Rate in Overweight and Obese Malaysian Subjects.Nephro-Urol Mon.3(1):15-22.

Abstract

Background and Aims: Overweight and obesity are significant risk factors for chronic kidney disease (CKD). Glomerular filtration rate (GFR) is the best index of renal function. We evaluated the accuracy of the Cockroft-Gault, MDRD and modified MDRD formulae in predicting GFR in overweight and obese subjects and also determined the relationship between Body Mass Index (BMI), weight and GFR.

Methods: Healthy volunteers with BMI ≥23kg/m² were recruited and subjected to blood and urine investigations, renal ultrasonography and 99mTc-DTPA renal scan. The correlation, accuracy and precision of the eGFR derived from each formula were compared with reference GFR as determined by 99mTc-DTPA.

Results: A total of 101 subjects with a median weight of 74.0kg (68.0-84.7) and median BMI of 29.6 kg/m² (27.2-33.2) were recruited. Their mean GFR 99mTc-DTPA was 120.3± 24.5ml/mm/1.73m². Although the eGFRs derived from all formulae correlated with GFR 99mTc-DTPA, only those derived from the MDRD and modified MDRD had small biases and better precision in estimating GFR. While GFR significantly correlated with the subjects' weight (p=0.036), it didn't with their BMI (p=0.302).

Conclusions: The MDRD-based formulae were better in estimating GFR in overweight and obese Malaysian subjects. GFR correlated with subjects' weight rather than BMI.

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