A419C Polymorphism of Glyoxalase I Gene: Renal Function and Histological Findings at 12 Months after Renal Transplantation

1Institute of Clinical Chemistry and Laboratory Diagnostics, First Faculty of Medicine and General University Hospital, Charles University, Czech Republic

2Institute of Clinical Chemistry and Laboratory Diagnostics, First Faculty of Medicine and General University Hospital, Charles University, marta.kalousova@seznam.cz, Czech Republic

Nephro-Urology Monthly:Vol. 2, issue 4; 504-513

Article type:Research Article

Received:Dec 14, 2009

Accepted:Jan 20, 2010

How to Cite:Marie JachymovaIrena BrabcovaAlexandra GermanovaJanka SlatinskaOto MestekIvo MatlTomas ZimaOndrej ViklickyMarta Kalousovaet al.A419C Polymorphism of Glyoxalase I Gene: Renal Function and Histological Findings at 12 Months after Renal Transplantation.Nephro-Urol Mon.2(4):504-513.

Abstract

Background and Aims: AGEs (advanced glycation end products) are involved in the pathogenesis of vascular damage and progression of chronic kidney diseases. They are detoxified by the glyoxalase (GLO) system. The aim of the study was to test whether A419C polymorphism of GLO I gene is associated with the outcome of kidney transplantation.

Methods: A419C polymorphism of the GLO I gene was assessed in 145 renal transplant recipients and its relationship to histological changes in 12 months protocol kidney graft biopsy and renal function was examined.

Results: Genotype frequencies of the studied polymorphism corresponded to the expected frequencies according to Hardy-Weinberg equilibrium. No significant differences among allelic and genotype frequencies among patients with normal histological findings, interstitial fibrosis/tubular atrophy and subclinical rejection and renal parameters were found. However, a trend towards lower levels of serum creatinine and proteinuria was observed in patients with CC genotype.

Conclusions: This is the first study of glyoxalase I gene polymorphism in patients with the transplanted kidney. Although no significant relationship of the GLO I genotype to the histology of the transplanted kidney and renal parameters could be found, a trend towards better outcome in patients with the CC genotype was observed.

Keywords

Biopsy

Interstitial Fibrosis and Tubular Atrophy

Glyoxalase I

Kidney Transplantation

Polymorphism

Receptor for Advanced Glycation End Products

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