Patient and Graft Outcome in Related, Unrelated and Deceased Renal Transplant Recipients: Single Center Experience

Reza Zafarghandi; Abbas Zeraati; Fatemeh Nazemian; Mohammad Shakibi; Mohammad Shakeri; Meisam Zafarghandi

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Patient and Graft Outcome in Related, Unrelated and Deceased Renal Transplant Recipients: Single Center Experience

Author(s):

Reza Mahdavi Zafarghandi^1,*,

Abbas Ali Zeraati²,

Fatemeh Nazemian³,

Mohammad Hadi Shakibi⁴,

Mohammad Taghi Shakeri⁵,

Meisam Mahdavi Zafarghandi⁶

1Department of Kidney Transplantation, Imam Reza Hospital, Mashad University of Medical Sciences, drrezamahdavi@yahoo.com, Khorasan-e-Razavi, IR.Iran

2Department of Kidney Transplantation, Imam Reza Hospital, Mashad University of Medical Sciences, Khorasan-e-Razavi, IR.Iran

3Department of Kidney Transplantation, Imam Reza Hospital, Mashad University of Medical Sciences, Khorasan-e-Razavi, IR.Iran

4Department of Kidney Transplantation, Imam Reza Hospital, Mashad University of Medical Sciences, Khorasan-e-Razavi, IR.Iran

5Department of Kidney Transplantation, Imam Reza Hospital, Mashad University of Medical Sciences, Khorasan-e-Razavi, IR.Iran

6Department of Kidney Transplantation, Imam Reza Hospital, Mashad University of Medical Sciences, Khorasan-e-Razavi, IR.Iran

Nephro-Urology Monthly:Vol. 2, issue 4; 514-519

Article type:Research Article

Received:Jan 02, 2010

Accepted:Apr 30, 2010

How to Cite:Reza Mahdavi ZafarghandiAbbas Ali ZeraatiFatemeh NazemianMohammad Hadi ShakibiMohammad Taghi ShakeriMeisam Mahdavi Zafarghandiet al.Patient and Graft Outcome in Related, Unrelated and Deceased Renal Transplant Recipients: Single Center Experience.Nephro-Urol Mon.2(4):514-519.

Abstract

Background and Aims: Nowadays with the extension and development of renal transplantation centers, the best treatment of the patients with ESRD is renal Transplantation. Renal allografts from deceased donors are being used in our center following legislation of the laws by Islamic parliament. Renal transplantation is evaluated by graft and patient survival. Therefore in this study graft and patient survival of recipients who received kidney from related, unrelated and deceased donors were reviewed.

Methods: Following preoperative examinations and live donor angiography, transplantation will be ready to perform. Renal transplantation was performed in 270 patients who received kidney from unrelated and 44 from related and 125 from deceased donors. Graft and patient survival were measured. Statistical analysis was performed using SPSS soft ware, Caplan - Meyer table, Cox regression and Long rank.

Results: In this study 439 patients were evaluated. Patients' age ranged between 8 and 71 years. There were no statistical differences among 3 groups (P > 0.1). One year graft survivals of recipients who received kidney from deceased, unrelated and related donors were 90%, 89% and 93%, respectively. Three year graft survival in the mentioned groups were 82%, 84% and 91%, respectively and 5 year graft survival were 81%, 90% and 81%, respectively. Statistical analysis showed no significant differences among 3 groups (P=0.241). One, three and five year recipient's survival were evaluated in patients who received kidney from deceased, unrelated and related donors. One year recipient survivals in the 3 groups were 95%, 93% and 98%, respectively; three year patient survivals were 94%, 98% and 93%, respectively and finally the 5 year patient survivals were 89%, 93% and 88%, respectively which showed no significant differences (P = 0.489).

Conclusion: Although graft and patient survivals are slightly better in recipients who received kidney from related donor, regarding static analysis there were no significant differences in 1, 3 and 5 years graft and patient survivals between recipients who received kidney from live (related or unrelated) and deceased donors. Therefore, deceased donors can be used as a valuable source in our country.

Keywords

Renal Transplantation

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