Investigation of the effect of Calendula officinalis extract on preventing radiotherapy-induced oral mucositis

Neda  Babaee; Dariush  Moslemi; Mohammad  Khalilpour; Fatemeh  Vejdani; Ali Bijani; Ali akbar Moghadamnia; Ahmad Ameri

Reports of Radiotherapy and Oncology

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Investigation of the effect of Calendula officinalis extract on preventing radiotherapy-induced oral mucositis

Authors:

Neda Babaee¹,

Dariush Moslemi^2,*,

Mohammad Khalilpour³,

Fatemeh Vejdani⁴,

Ali Bijani⁵,

Ali akbar Moghadamnia⁶,

Ahmad Ameri⁷

1General dentist, Assistant professor of oral diseases, Babol University of Medical Sciences, Babol, Iran

2Radiation Oncologist, Babol University of Medical Sciences, Babol, Iran

3General dentist, Babol University of Medical Sciences, Babol, Iran

4General dentist, Babol University of Medical Sciences, Babol, Tehran, Iran

5General practitioner, Non-Communicable Pediatric Disease Research Center, Babol University of Medical Sciences, Babol, Iran

6Professor of pharmacology, Department of Pharmacology, Babol University of Medical Sciences, Babol, Iran

7Associate professor of radiation oncology, Department of Radiation Oncology, Imam Hossein Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran

Reports of Radiotherapy and Oncology:Vol. 1, issue 1; 3-9

Published online:Jun 01, 2013

Article type:Research Article

Received:Mar 23, 2013

Accepted:May 02, 2013

How to Cite:Neda BabaeeDariush MoslemiMohammad KhalilpourFatemeh VejdaniAli BijaniAli akbar MoghadamniaAhmad Ameriet al.Investigation of the effect of Calendula officinalis extract on preventing radiotherapy-induced oral mucositis.1(1):e2378.

Abstract

Objective: The objective of this study was to investigate the effect of Calendula officinalis mouthwash on preventing radiotherapy-induced Oral Mucositis

Materials and Methods: Patients with head and neck cancers referred to our center for radiotherapy were divided into two groups, one receiving drug and the other group receiving placebo. Patients in the drug group received 2% Calendula gel. Oral Mucositis Assessment Scale was used to evaluate oral mucositis intensity at the end of each week. The scale of mucositis at the end of each week was compared between groups.

Results: Calendula gel significantly decreased the intensity of oral mucositis as compared to placebo at the end of the 2nd (p=0.019), 3rd (p<0.0001) and 6th week (p=0.031).

Conclusion: Calendula gel could be effectively used to decrease the intensity of radiotherapy- induced oral mucositis.

Keywords

Radiotherapy

muscositis

Calendula officinalis

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