Investigation of the effect of Calendula officinalis extract on preventing radiotherapy-induced oral mucositis

authors:

avatar Neda Babaee 1 , avatar Dariush Moslemi 2 , * , avatar Mohammad Khalilpour 3 , avatar Fatemeh Vejdani 4 , avatar Ali Bijani 5 , avatar Ali akbar Moghadamnia 6 , avatar Ahmad Ameri 7

General dentist, Assistant professor of oral diseases, Babol University of Medical Sciences, Babol, Iran
Radiation Oncologist, Babol University of Medical Sciences, Babol, Iran
General dentist, Babol University of Medical Sciences, Babol, Iran
General dentist, Babol University of Medical Sciences, Babol, Tehran, Iran
General practitioner, Non-Communicable Pediatric Disease Research Center, Babol University of Medical Sciences, Babol, Iran
Professor of pharmacology, Department of Pharmacology, Babol University of Medical Sciences, Babol, Iran
Associate professor of radiation oncology, Department of Radiation Oncology, Imam Hossein Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran
Reports of Radiotherapy and Oncology: Vol.1, issue 1; 3-9
published online: June 01, 2013
article type: Research Article
received: March 23, 2013
accepted: May 02, 2013

how to cite: Babaee N , Moslemi D , Khalilpour M , Vejdani F , Bijani A, et al. Investigation of the effect of Calendula officinalis extract on preventing radiotherapy-induced oral mucositis. Rep Radiother Oncol. 2013;1(1):e2378. 

Abstract

Objective: The objective of this study was to investigate the effect of Calendula officinalis mouthwash on preventing radiotherapy-induced Oral Mucositis
Materials and Methods: Patients with head and neck cancers referred to our center for radiotherapy were divided into two groups, one receiving drug and the other group receiving placebo. Patients in the drug group received 2% Calendula gel. Oral Mucositis Assessment Scale was used to evaluate oral mucositis intensity at the end of each week. The scale of mucositis at the end of each week was compared between groups.
Results: Calendula gel significantly decreased the intensity of oral mucositis as compared to placebo at the end of the 2nd (p=0.019), 3rd (p<0.0001) and 6th week (p=0.031).
Conclusion: Calendula gel could be effectively used to decrease the intensity of radiotherapy- induced oral mucositis.

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