Vinorelbine and Docetaxel Combination as the First Line Treatment in Patients with Metastatic Breast Cancer: Results of a Multi-centric Phase II Trial in Iran

Ahamad Ameri; Behrouz Shahrad; Abollah Fazlalizadeh; Hossein Madani; Ahmad Mousavizadeh; Shiva Moghadam

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Vinorelbine and Docetaxel Combination as the First Line Treatment in Patients with Metastatic Breast Cancer: Results of a Multi-centric Phase II Trial in Iran

Authors:

Ahamad Ameri¹,

Behrouz Shahrad¹,

Abollah Fazlalizadeh¹,

Hossein Madani²,

Ahmad Mousavizadeh²,

Shiva Moghadam^1,*

1Department of Radiation Oncology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2Department of Radiation Oncology, Shohada Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Reports of Radiotherapy and Oncology:Vol. 1, issue 2; 51-7

Published online:Sep 01, 2013

Article type:Research Article

Received:May 14, 2013

Accepted:Jul 26, 2013

How to Cite:Ahamad AmeriBehrouz ShahradAbollah FazlalizadehHossein Madani Ahmad MousavizadehShiva Moghadamet al.Vinorelbine and Docetaxel Combination as the First Line Treatment in Patients with Metastatic Breast Cancer: Results of a Multi-centric Phase II Trial in Iran.1(2):e2384.

Abstract

Introduction: We conducted a multi-centric phase II study to evaluate the tumor response and safety of the combination of vinorelbin and docetaxel in treatment of metastatic breast cancer patients.

Patients and Methods: Forty one metastatic breast cancer patients, who had at least one measurable lesion and had not been treated for metastasis before, were enrolled from March 2006 to June 2009. Treatment contained vinorelbine 25mg/m2 [Click and drag to move] [Click and drag to move] IV and docetaxel 30mg/m2 [Click and drag to move] [Click and drag to move] at day 1 and 8. Cycles were repeated every 21 days for 6 cycles. We evaluated response to chemotherapy every three weeks and toxicity every week.

Results: The mean age of patients was 50.4 years (range 30-81). Twenty eight patients (68.2%) had received prior neoadjuvant anthracycline based chemotherapy. No patient had received adjuvant chemotherapy within the
last 3 months. Twenty four patients (58.3%) had two or more metastatic sites. Thirty six patients were evaluable for their response. An objective tumor response (either complete response or partial response) was achieved in 32 (88.8%) and complete response was seen in 9 (25%) patients. Thirteen patients (31.6%) developed grade 3-4 neutropenia and neutropenic fever was reported in 11 (26.8%). Grade 3 anemia was observed in 1 patient (2.4%). No grade 4 non-hematological toxicity was noted and the most frequent grade 3 non-hematological toxicities were hair loss (39%), stomatitis (7.3%) and diarrhea (4.8%). Median time to progression was 7 months and median overall survival was 11 months.
Conclusion: Vinorelbine-docetaxel combination shows a considerable tumor response and manageable toxicity
as the first line treatment for metastatic breast cancer. It seems logical to conduct phase III trials to further
evaluate this regimen.

Keywords

Metastatic breast cancer

chemotherapy

vinorelbine

docetaxel

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