Abstract
Glucose or N-Acetylglucosamine induce similar filamentous growth and a specific calcium and magnesium-dependent intracellular glycoprotein pattern in C. albicans at 37 C in vitro. Both filament growth and its associated glycoprotein pattern are inhibited by calcium ions. The above inhibition can be reversed by magnesium ions, though only in N-Acetylglucosamine- but not in glucose-treated cells. Our data show that in contrast to glucose, N-Acetylglucosamine more than being only a carbon source, it is a key factor for filamentous growth and intracellu- lar protein glycosylation to occur, and thus, it may effect the interaction of C. albicans with its host in a calcium- and magnesium-dependent manner.
Keywords
C.albicans filamentous growth glycosylation mannoproteins N-Acetyl Glucosamine.
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© 2008, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.