The Effect of Myrtus communis Extract on Liver Enzymes and Blood Biochemical Factors in Diabetic Adult Male Rats

Mohammad Yazdani; Zahra Zamani; Moghtar Moghtari; Mohsen Nozari; Habibollah  Johari

Zahedan Journal of Research in Medical Sciences

The Official Journal of Zahedan University of Medical Sciences

Current Issue All Issues In Press Articles Accepted Manuscripts Search

Journal Information Boards and Committees Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Contact Us Support Reviewer and AE Registration Form

APC

Authors Guide Submit Manuscript

The Effect of Myrtus communis Extract on Liver Enzymes and Blood Biochemical Factors in Diabetic Adult Male Rats

Author(s):

Mohammad Yazdani¹,

Zahra Zamani²,

Moghtar Moghtari²,

Mohsen Nozari³,

Habibollah Johari^4,*

1Department of Agriculture, Firouz Abad Branch , Islamic Azad University, Firouz Abad, Iran

2Department of Physiology, Kazeron Branch , Islamic Azad University, Kazeron, Iran

3Department of Physiology, Kazeron Branch , Islamic Azad University, Kazeron , Iran

4Departmemt of Physiology, Darab Branch, Islamic Azad University, Darab, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 16, issue 10

Published online:Feb 05, 2014

Article type:Research Article

Received:Aug 28, 2013

Accepted:Sep 18, 2013

How to Cite:Mohammad Yazdani Zahra ZamaniMoghtar MoghtariMohsen NozariHabibollah JohariThe Effect of Myrtus communis Extract on Liver Enzymes and Blood Biochemical Factors in Diabetic Adult Male Rats.Zahedan J Res Med Sci.16(10):null-null.

Abstract

Background: The aim of this study was the effect of Myrtus communis extract on liver enzymes and blood biochemical factors in diabetic adult male rats.

Materials and Methods: This study has been carried out experimentally and completely random. Seventy adult male Wistar rats were divided in 7 groups including: control which received no treatment, sham who received 2 mL of distilled water, the 1st, 2nd and 3rd experimental groups which received 0.75, 1.5 and 3 mg/kg Myrtus communis leaf extract respectively, the 4th experimental group as the diabetic control group who received streptozotocin (60 mg/kg) and the 5th experimental group as the diabetic treatment group who received 3 mg/kg of extract. This experiment lasted 14 days with prescript orally. After this period, all the rats, were weighted, anesthetized and blood samples were taken from the heart centrifuged and sera were evaluated for the concentration of various factors. In addition liver were removed and sliced.

Results: According to the obtained results, the plasma concentration of liver enzyme (alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase), cholesterol and glucose presented a significant decrease at (p≤0.05). Whereas no significant change were seen in body weight, triglyceride, urea, albumin and total protein. Histological studies of the liver tissue showed no significant difference among various groups.

Conclusion: Myrtus communis is comprise of collections of flavonoids and other various components with antioxidant and anti inflammatory properties. Thence it can effective in treatment of liver diseases and decrease of blood sugar and cholesterol in diabetes mellitus patients.

Keywords

Fulltext

Fulltext is availale in the PDF.

References

1.
Refrences are available in PDF.

comments