The Effect of Chelidonium majus Extract on the Lipid Profile and Activity of Pituitary-Gonadal Axis in Hypercholesterolemic Rats

Ali Zarei; Saeed Changizi-Ashtiyani; Azam Rezaei; Hassan Sheidaee; Fatemeh Nabiyoni

Zahedan Journal of Research in Medical Sciences

The Official Journal of Zahedan University of Medical Sciences

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The Effect of Chelidonium majus Extract on the Lipid Profile and Activity of Pituitary-Gonadal Axis in Hypercholesterolemic Rats

Author(s):

Ali Zarei¹,

Saeed Changizi-Ashtiyani^2,*,

Azam Rezaei³,

Hassan Sheidaee⁴,

Fatemeh Nabiyoni ⁴

3Department of Physiology, Arsanjan Branch , Islamic Azad University, Arsanjan, Iran

4Department of Physiology, Science and Research Br anch, Azad University of Damghan, Damghan, Iran

4Department of Physiology, Arsanjan Branch , Islamic Azad University, , Arsanjan, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 16, issue 10

Published online:Jul 17, 2013

Article type:Research Article

Received:Apr 27, 2013

Accepted:Jun 29, 2013

How to Cite:Ali ZareiSaeed Changizi-Ashtiyani Azam RezaeiHassan Sheidaee Fatemeh Nabiyoni The Effect of Chelidonium majus Extract on the Lipid Profile and Activity of Pituitary-Gonadal Axis in Hypercholesterolemic Rats.Zahedan J Res Med Sci.16(10):null-null.

Abstract

Background: Over the past centuries, global population has increased at different rates and so has been the case with cardiovascular diseases. Therefore, given the importance of population and cholesterol control, the purpose of this study is to investigate the effect of Chelidonium majus (C. majus) aerial parts extract on the lipid profile and prolactin levels and the activity of pituitary-gonadal axis in hypercholesterolemic rats.

Materials and Methods: In this experimental study, 35 Wistar rats were selected and categorized into 5 groups. The control group had ordinary diet, the model group had high-fat diet, and experimental groups consisted of hypercholesterolemic rats that respectively received minimal dosages of 100, 200 and 300 mg/kg of C. majus extract. After 21 days, blood samples were taken and the factors of interest were measured. Then, the gathered data were analyzed using SPSS-11.5.

Results: The amount of triglyceride and cholesterol were increased in the model group compared to the control group whereas the same items were decreased in the experimental group. C. majus extract also decreased testosterone and increased prolactin and gonadotropins.

Conclusion: In this study, C. majus extract resulted in decreased fat and testosterone levels as well as increased prolactin level; however, since many sources have informed of the toxicity of this plant, cautious use of the plant is advised.

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