Amelioration of Glomerulosclerosis by Satureja khozestanica Essential Oil in A lloxan-Induced Diabetic Rats


avatar Majid Tavafi 1 , avatar Hassan Ahmadvand 2 , *

Department of Anatomy, Lorestan Univers ity of Medical Sciences , Khoramabad, Iran
Department of Biochemistry, Razi Herbal Researches Center , Lorestan University of Medical Sciences,, Khoramabad, Iran

how to cite: Tavafi M, Ahmadvand H . Amelioration of Glomerulosclerosis by Satureja khozestanica Essential Oil in A lloxan-Induced Diabetic Rats. Zahedan J Res Med Sci. 2014;16(10): -.


Background: Satureja khuzestanica, an endemic plant of Iran, has been reported to be used traditionally to treat diabetes. We examined possible protective effect of Satureja khozestanica essential oil (SKE) on glomerulosclerosis in alloxan-induced type 1 diabetic rats.
Materials and Methods: In this experimental study, 30 Sprage-dawley male rats were divided into 3 groups randomly; group 1 as control, group 2 diabetic untreated, and group 3 treatments with SKE by 500 ppm in drinking water, respectively. Diabetes was induced in the second and third groups by alloxan injection subcutaneously. After 8 weeks, animals were anaesthetized; livers and kidneys were then removed immediately. Kidney paraffin sections were prepared and stained by periodic acid Schiff method. Glomerular volume and leukocyte infiltration were estimated by stereological rules and glomerular sclerosis was studied semi-quantitatively.
Results: Flow treatment of diabetic animals with SKE could significantly inhibit glomerular hypertrophy (22%) leukocyte infiltration (31%) and glomerulosclerosis (20%) in comparison with the diabetic untreated group.
Conclusion: The findings showed that SKE alleviates loss of glomerular volume, leukocyte infiltration, and glomerulosclerosis and exerts beneficial effects on the lipid peroxidation in alloxan-induced type 1 diabetic rats.


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