In-Vitro Antibacterial Properties of Sage (Salvia officinalis) Ethanol Extract against Multidrug Resistant Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae

Monir Doudi; Sima Yahyaabadi; Elham  Mosafa

Zahedan Journal of Research in Medical Sciences

The Official Journal of Zahedan University of Medical Sciences

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In-Vitro Antibacterial Properties of Sage (Salvia officinalis) Ethanol Extract against Multidrug Resistant Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae

Author(s):

Monir Doudi ¹,

Sima Yahyaabadi²,

Elham Mosafa^2,*

2Department of Biology, Islamic Azad University, Falavarjan Branch, Isfahan, Iran

2Department of Microbiology, Islamic Azad University, Falavarjan Branch, Isfahan, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 16, issue 10

Published online:Jul 13, 2013

Article type:Research Article

Received:Apr 23, 2013

Accepted:May 15, 2013

How to Cite:Monir Doudi Sima YahyaabadiElham MosafaIn-Vitro Antibacterial Properties of Sage (Salvia officinalis) Ethanol Extract against Multidrug Resistant Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae.Zahedan J Res Med Sci.16(10):null-null.

Abstract

Background: Due to excessive consumption of synthetic drugs, drug resistance rate of pathogenic bacteria is increasing and the need to find new compounds is necessary. The aim of this study was to investigate the antibacterial effect of ethanol extract of, sage to the four species of common pathogenic bacteria resistant to multiple drugs in vitro such as: Staphylococcus aureus (50 strains), Escherichia coli (50 strains), Pseudomonas aeruginosa (50 strains) and Klebsiella pneumonia (50 strains).

Materials and Methods: In this experimental study, antibacterial effect of ethanol extract of sage plants on the development of multi-drug resistant bacteria was performed by well diffusion at concentrations of 50, 400, 100 mg/mLand microdilution method.

Results: Ethanol extracts of sage in well diffusion method showed significant inhibitory effect on the growth of isolated bacteria. The results indicate the inhibitory effects of ethanol extract of sage with MIC (Minimum Inhibitory Concentration)=18.75 mg/mL for S. aureus, MIC=26.56 mg/mL for E. coli, MIC=33.75 mg/mL for P. aeruginosa and with MIC=31.25 mg/mL for K. pneumoniae.

Conclusion: In relation with the antibacterial effect of ethanol extracts of Sage on the multi-drug resistant bacteria the use of herbs as an alternative to antibiotics after pharmacological studies, for treatment recommended.

Keywords

Salvia Officinalis

In-Vitro

Drug Resistance

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