Phytochemical Analysis, Antibacterial Activity of Marrubium vulgare L against Staphylococcus aureus in vitro

Hamde Khaje; Saphora Bazi; Negar Amini-Borojeni; Abbas Ali Niazi; Mohammad Bokaeian; Elham Saboori; Saeide  Saeidi

Zahedan Journal of Research in Medical Sciences

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Phytochemical Analysis, Antibacterial Activity of Marrubium vulgare L against Staphylococcus aureus in vitro

Author(s):

Hamde Khaje¹,

Saphora Bazi¹,

Negar Amini-Borojeni²,

Abbas Ali Niazi³,

Mohammad Bokaeian⁴,

Elham Saboori⁵,

Saeide Saeidi^6,*

1Department of Biology, Faculty of Sciences, Payam-e-Noor University, Isfahan, Iran

2Agricultural Biotechnology Research Institute, Zabol University, Zabol, Iran

3Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

4Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences,, Zahedan, Iran

5Department of Agricultural Biotechnology, Zabol University, Zabol, Iran

6Saeide Saeidi, Department of Biology, Faculty of Sciences, Science and Research Branch, Islamic Azad University, Kerman, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 16, issue 10; 60-64

Published online:Sep 10, 2013

Article type:Research Article

Received:Jul 02, 2013

Accepted:Jul 20, 2013

How to Cite:Hamde KhajeSaphora BaziNegar Amini-BorojeniAbbas Ali NiaziMohammad BokaeianElham SabooriSaeide Saeidiet al.Phytochemical Analysis, Antibacterial Activity of Marrubium vulgare L against Staphylococcus aureus in vitro.Zahedan J Res Med Sci.16(10):60-64.

Abstract

Background:Herbal medicines are the major remedy in traditional medical systems and made a great contribution in maintaining human health and in preventing many infectious diseases. The present study was carried out to determine the potential antibacterial effect of ethanol extracts and essential oil of Marrubium vulgare L. against Staphylococcus aureus which is antibiotic resistant.

Materials and Methods:All 17 strains of S. aureus isolated from nose and throat sample from 160 healthy subjects, hospital staffs and inpatient in the city of Zabol (Amir Al-Momenin hospital, Zabol, south-eastern Iran) were screened during years 2010-2011. In this study, the essential oil of Marrubium vulgare L. obtained by hydrodistillation was analyzed by gas chromatography coupled to mass spectrometry (GC-MS) in order to determine their chemical composition. The minimum inhibitory concentrations were investigated to characterize the antimicrobial activities of this essential oil and extract.

Results:Thirty-one components in the oil of Marrubium vulgare were identified. The results demonstrated that the major components of the essential oil were γ-Eudesmol (11%), Germacrene (10%), D-Citronelly formate (10%), β-Citronellol (8%), Geranyl tiglate (7.1%), Geranyl formate (6.02%). The least MIC value of extract M. vulgare was 2.5 mg/mL and the highest MIC value of essential oil M. vulgare was 2.5 mg/mL.

Conclusion:This investigation showed that the M. vulgare essential oil and extract has a potent antimicrobial activity against S. aureus. The present studies confirm the use of this essential oil and extract as antibacterial agent. Further research is required to evaluate the practical values of therapeutic applications.

Keywords

Phytochemical Analysis

Antibacterial Activity

Marrubium Vulgare L

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