The Evaluation of Psychological Factor and Salivary Cortisol and IgA Levels in Patients with Oral Lichen Planus

authors:

avatar Tahereh Nosratzehi 1 , avatar Fateme Arbabi-Kalati 2 , * , avatar Saeedeh Salimi 3 , avatar Elham Honarmand 4

Department of Oral Medicine, Dental Resear ch Center, Zahedan University Of Medical Science, Faculty of Dentistry, Zahedan, Iran
Department of Oral Medicine, Genetics of Non-Communicable Disease Research Center, Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran
Department of Biochemistry, Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
Dentist, Zahedan University of Medical Sciences, Zahedan, Iran
Zahedan Journal of Research in Medical Sciences: Vol.16, issue 7
published online: February 03, 2014
article type: Research Article
received: August 25, 2013
accepted: January 15, 2014

How To Cite Nosratzehi T , Arbabi-Kalati F , Salimi S, Honarmand E. The Evaluation of Psychological Factor and Salivary Cortisol and IgA Levels in Patients with Oral Lichen Planus. Zahedan J Res Med Sci. 2014;16(7): -. 

Abstract

Background: Oral lichen planus (OLP) is a chronic immunological disorder with unknown etiology. The aim of this study was to determine psychological factors and salivary cortisol, IgA level in patients with oral lichen planus.
Materials and Methods: In this experimental study 20 patients with OLP and healthy person were admitted to this study. Saliva samples were collected between 9-10 Am. saliva cortisol, IgA level was detected by ELIZA method. In this study, patients with anxiety and depression were measured using the SCL-90 questionnaire. Data analyzed by t-test.
Results: The mean salivary cortisol level in patients with OLP was 3.2±1.9 ng/mL and the mean saliva cortisol level in healthy person was 3.5±1.9 ng/mL. Significant difference was observed in the salivary cortisol levels in the 2 study groups (p=0.04). The mean salivary IgA level in patients with OLP was 0.69±0.29 ng/mL and the mean saliva IgA level in healthy person was 0.9±0.43 ng/mL but no significant difference was observed in the salivary cortisol levels in the 2 study groups. Results showed that anxiety levels in patients with oral lichen planus were slightly higher than controls but there was no significant difference between healthy subjects.
Conclusion: Finding revealed the mean salivary cortisol level in patient with OLP less than healthy persons. Significant difference was observed in the salivary cortisol levels in the 2 study groups. Based on the t-student test, no significant difference was observed in the salivary IgA levels in the 2 study groups. Anxiety levels in patients with oral lichen planus were slightly higher than controls.

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