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The Effect of Eccentric Exercise on Total Anti-Oxidant Capacity, Reduced Glutathione and Malondialdehyde Levels in Active Women


avatar Parichehr Hanachi 1 , avatar Afsaneh Shemshaki 2 , avatar Sekineh Norouziyan 3 , *

1 Tehran , Iran

2 Department of Physical Education, Faculty of Physical Education and Sport Sciences, Alzahra University, Tehran, Iran

3 Department of Physical Education , Alzahra University, Qaemshahr, Iran

How to Cite: Hanachi P, Shemshaki A, Norouziyan S . The Effect of Eccentric Exercise on Total Anti-Oxidant Capacity, Reduced Glutathione and Malondialdehyde Levels in Active Women. Zahedan J Res Med Sci. 2014;16(6): -.


Zahedan Journal of Research in Medical Sciences: 16 (6)
Published Online: February 23, 2013
Article Type: Research Article
Received: July 31, 2012
Accepted: October 18, 2012


Background: Although exercise can increase free radicals by generating oxidative stress, it also can decrease them by increasing the antioxidant enzymes in the body as well. The purpose of this study is to investigate the eccentric activity on some oxidative and anti-oxidative factors pertaining to blood plasma of PE women immediately after the exercise.
Materias and Methods: Sixteen female students have been volunteered in this study randomly divided into two groups including eccentric training group and control group. The blood samples were drawn from the subjects one hour before and immediately after the exercise to measure the reduced Glutathione (GSH), Malondialdehyde (MDA) and total anti-oxidant capacity (TAC) levels. The data were analyzed by SPSS-13 software using the one-way analysis of variance, one-way ANOVA test, (to determine the differences between groups) at the confidence level of 90% (p<0.05).
Results: The results has shown that the TAC, MDA, GSH levels after the eccentric exercise increased significantly compared to pre-exercise (p=0.001, p=0.001, p=0.033). The GSH and MDA levels also after the eccentric exercise were significantly higher than the pre-exercise compared to control group.
Conclusion: It seems that sever eccentric exercise is an important stimulus making significant changes in body’s anti-oxidative system and has the ability to improve the anti-oxidant capacities too.


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