Hepatitis in Patients with Crimean –Congo Hemorrhagic Fever

authors:

avatar Maliheh Metanat 1 , avatar Batool Sharifi-Mood 2 , * , avatar Roya Alavi - Naini 3 , avatar Ali Amjadi 3

Infectious Diseases and Tropical Medicine Research Cente r , Zahedan University of Medical Sciences, Zahedan, Iran
Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
Infectious Diseases and Tropical Medicine Research Cente r , Zahedan University of Medical Sciences , Zahedan, Iran
Zahedan Journal of Research in Medical Sciences: Vol.16, issue 4; 32-34
published online: June 15, 2015
article type: Short Communication
received: April 18, 2013
accepted: May 15, 2013

how to cite: Metanat M, Sharifi-Mood B , Alavi - Naini R, Amjadi A. Hepatitis in Patients with Crimean –Congo Hemorrhagic Fever. Zahedan J Res Med Sci. 2014;16(4): 32-34. 

Abstract

 
Background: Crimean–Congo hemorrhagic fever (CCHF) is a viral disease and causing approximately 30% fatality rate. Recent studies have been reported that hepatitis in CCHF patients is with high mortality. The aim of this study was to determine the prevalence of hepatitis in the CCHF cases and also detect the mortality rate among patients with hepatitis.
Materials: and Methods: The present study was conducted in patients with CCHF who were hospitalized in Boo-Ali hospital in Zahedan between Oct 2009 to Feb 2012. Liver function tests including aminotransferase enzymes and prothrombin time and mortality rate were evaluated.
Result: Among 53 patients with CCHF, hepatitis was seen in 19 patients (45%). Nine patients died (21%). All dead patients had a serum aminotransaminase level ≥10 times the upper normal limit.
Conclusion: Our study showed that hepatitis is prevalent in CCHF patients and a serum aminotransaminase level ≥5 times the upper normal limit (UNL) is a risk factor for severe disease and high mortality.

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