Effect of Matricaria recutita Hydroalcoholic Extract on Anxiety Behavior in Mice by Hole-Board Test

Mahnnaz  Kesmati; Loghman Izadi; Meysam Mard - Soltan

Zahedan Journal of Research in Medical Sciences

The Official Journal of Zahedan University of Medical Sciences

Current Issue All Issues In Press Articles Accepted Manuscripts Search

Journal Information Boards and Committees Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Contact Us Support Reviewer and AE Registration Form

APC

Authors Guide Submit Manuscript

Effect of Matricaria recutita Hydroalcoholic Extract on Anxiety Behavior in Mice by Hole-Board Test

Author(s):

Mahnnaz Kesmati^1,*,

Loghman Izadi²,

Meysam Mard - Soltan³

1Department of Biology, Faculty of Sciences, Shahid Chamran University, Ahvaz, Iran

2Department of Biology, Faculty of Sciences, Shahid Chamran University, Ahvaz, Iran

3Medical Education Development Center, Dezful University of Medical Sciences, Dezfu, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 16, issue 3; 21-24

Published online:Mar 12, 2013

Article type:Research Article

Received:Aug 30, 2012

Accepted:Oct 20, 2012

How to Cite:Mahnnaz KesmatiLoghman IzadiMeysam Mard - SoltanEffect of Matricaria recutita Hydroalcoholic Extract on Anxiety Behavior in Mice by Hole-Board Test.Zahedan J Res Med Sci.16(3):21-24.

Abstract

Background: An anxiolytic effect of chamomile has been shown in various studies. In the previous study was indicated that the Iranian specious of chamomile, Matricaria recutita (M. recutita) hydro alcoholic extract acts sex dependent in the elevated plus maze. It showed anxiolytic effect in the presence and absence of male mice gonads but not in female mice. In this study we examined the anxiety model dependent of M. recutita in another unconditioned anxiety model, hole-board test, because there are various model for evaluating anxiety with specific properties.

materials and Methods: Adult male and female of N-MARI mice (N=120) were prepared and each sex divided into 5 groups (each group consist of 12 animals): control group, saline and 3 experimental groups that received different doses (10, 30, and 50 mg/kg, intraperitoneally) of M. recutita hydro alcoholic extract. Hole-board instrument was used to anxiety measurement, and delay time, the devour number and maintained time in the holes, as anxiety indices in this device, were evaluated.

Results: There were not any significant differences between anxiety indices in control and saline groups in both sexes. M. recutita extract (10, 30 and 50 mg/kg via i.p.) reduced significantly an anxiety in both male and female mice and an anxiolytic effects of 30 mg/kg than the other doses were considerably higher.

Conclusion: It seems an anxiolytic effect of M. recutita is independent to anxiety model and the similarity effect at male and female mice in this model emphasizes the validity of the model.

Keywords

Matricaria Recutita

Anxiety

Mouse

Fulltext

Fulltext is availale in the PDF..

References

1.
Refrences are available in PDF.

comments