The  Prophylactic  Effect of Vitamin C on Oxidative Stress Indexes Following  Exposure to Radio Frequency  Wave Generated by a BTS Antenna Model in Rat  Liver  and Kidne

Abolfazl Akbari; Gholamali  Jelodar; Saeed Nazifi

Zahedan Journal of Research in Medical Sciences

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The Prophylactic Effect of Vitamin C on Oxidative Stress Indexes Following Exposure to Radio Frequency Wave Generated by a BTS Antenna Model in Rat Liver and Kidne

Author(s):

Abolfazl Akbari¹,

Gholamali Jelodar^1,*,

Saeed Nazifi²

1Department of Physiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

2Department of Clinical Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 16, issue 2; 19-23

Published online:Jun 09, 2013

Article type:Research Article

Received:Mar 11, 2012

Accepted:Apr 24, 2013

How to Cite:Abolfazl AkbariGholamali JelodarSaeed NazifiThe Prophylactic Effect of Vitamin C on Oxidative Stress Indexes Following Exposure to Radio Frequency Wave Generated by a BTS Antenna Model in Rat Liver and Kidne.Zahedan J Res Med Sci.16(2):19-23.

Abstract

Background: Radio frequency wave (RFW) generated by base transceiver station (BTS) has been reported to make deleterious effects on liver and kidney, possibly through oxidative stress. This study was conducted to evaluate the effect of radiofrequency wave (RFW)-induced oxidative stress in the liver and kidney and the prophylactic effect of vitamin C on this organs by measuring the antioxidant enzymes activity including: glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT), and malondialdehyde (MDA).

Materials and Methods: In this experimental study, thirty-two adult male Sprague-Dawley rats were randomly divided into four experimental groups and treated daily for 45 days as follows: control, vitamin C (L-ascorbic acid 200 mg/kg of body weight/day by gavage), test (exposed to 900MHz RFW) and the treated group (received vitamin C in addition to exposure to RFW). At the end of the experiment all animals were sacrificed and their liver and kidney were removed and were used for measurement of antioxidant enzymes and MDA activity.

Results: The results indicate that exposure to RFW in the test group decreased antioxidant enzymes activity and increased MDA compared with the control groups (p<0.05). In the treated group vitamin C improved antioxidant enzymes activity and reduced MDA compared to the test group (p<0.05).

Conclusion: It can be concluded that RFW causes oxidative stress in liver and kidney, and vitamin C improves the antioxidant enzymes activity and decreases MDA.

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