The Effects of Essential Oil of Galbanum on Caffeine Induced-Cleft palate in Rat Embryos

Fardokht Rashidi; Mahmood  Khaksary-Mahabady; Reza Ranjba; Hossein Najafzadeh - Varz

Zahedan Journal of Research in Medical Sciences

The Official Journal of Zahedan University of Medical Sciences

Current Issue All Issues In Press Articles Accepted Manuscripts Search

Journal Information Boards and Committees Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Contact Us Support Reviewer and AE Registration Form

APC

Authors Guide Submit Manuscript

The Effects of Essential Oil of Galbanum on Caffeine Induced-Cleft palate in Rat Embryos

Author(s):

Fardokht Rashidi¹,

Mahmood Khaksary-Mahabady^2,*,

Reza Ranjba³,

Hossein Najafzadeh - Varz⁴

1Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

2Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

3Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz , Ahvaz, Iran

4Department of Pharmacology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 16, issue 2; 37-41

Published online:Jan 07, 2013

Article type:Research Article

Received:Sep 28, 2012

Accepted:Nov 20, 2012

How to Cite:Fardokht RashidiMahmood Khaksary-MahabadyReza RanjbaHossein Najafzadeh - VarzThe Effects of Essential Oil of Galbanum on Caffeine Induced-Cleft palate in Rat Embryos.Zahedan J Res Med Sci.16(2):37-41.

Abstract

Background: Caffeine at high doses is a known rodent teratogen and induces limb malformations along with cleft palate in various strains of rats and mice. The teratogenic effects of some drugs can be prevented by the application of antioxidant drugs and stimulation of the maternal immune system. Also, there is some evidence that galbanum is antioxidant. Therefore, in this study, the prophylactic effect of galbanum on teratogenic effects of caffeine was evaluated.

Materials and Methods: This experimental study was performed on 28 pregnant rats that were divided into four groups. Control group received normal saline and test groups received caffeine (80 mg/kg), caffeine (80 mg/kg) plus galbanum (200 mg/kg) and galbanum (200 mg/kg), intraperitonealy at 9-11th days of gestation, respectively. Fetuses were collected at 20th day of gestation and after determination of weight and length; they were stained by Alizarin red - Alcian blue method.

Results: Cleft palate incidence was 33.3%, in caffeine group and decreased to 8.3% by galbanum. The mean of weight and length of fetuses from rat that received galbanum were significantly greater than those received only caffeine.

Conclusion: It is concluded that galbanum decreased cleft palate induced by caffeine; but its mechanism needs more details evaluation.

Keywords

Fulltext

Fulltext is availale in the PDF.

References

1.
References are available in the PDF.

comments