Morphine Sulphate Toxicity on Liver Function Tests in Fructose-Induced Insulin Resistant Male Rats

Mohammad Reza  Shahraki; Elham Shahraki; Hamideh Mirshekari; Ahmad Reza Shahraki

Zahedan Journal of Research in Medical Sciences

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Morphine Sulphate Toxicity on Liver Function Tests in Fructose-Induced Insulin Resistant Male Rats

Author(s):

Mohammad Reza Shahraki^1,*,

Elham Shahraki²,

Hamideh Mirshekari³,

Ahmad Reza Shahraki⁴

1Department of Physiology, Zahedan University of Medical Sciences, Zahedan, Iran

2Department of Internal Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

3Zahedan Health Center, Zahedan University of Medical Sciences, Zahedan, Iran

4Chabahar Health Center, Zahedan University of Medical Sciences, Zahedan Branch, Member of Young Researches Club of Islamic Azad University, Zahedan, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 16, issue 2; 50-53

Published online:Mar 12, 2013

Article type:Research Article

Received:Mar 18, 2015

Accepted:Jan 21, 2013

How to Cite:Mohammad Reza ShahrakiElham ShahrakiHamideh MirshekariAhmad Reza ShahrakiMorphine Sulphate Toxicity on Liver Function Tests in Fructose-Induced Insulin Resistant Male Rats.Zahedan J Res Med Sci.16(2):50-53.

Abstract

Background: Since liver is a gland which has an important role in drug metabolism, the present study was conducted to evaluate the effect of a single dose and repeated administration of morphine on LFT, blood sugar and fasting insulin resistance index in fructose- fed male rats.

Materials and Methods: The experiment was performed on 36 Wistar-Albino male rats, which were divided into a control (A) and three tests groups (B, C and D). The control group consumed tap water, but the test groups consumed fructose-enriched water (10%, w/v) and received null, single, and repeated doses of morphine, respectively. At the end, animals were anesthetized and blood samples were collected. Liver enzymes, insulin and insulin resistance were measured. Data were analyzed by SPSS-11, using ANOVA and Tukey tests as post hoc test. Results were expressed as mean±SD and Statistical differences were recognized significant by p<0.05.

Results: The results showed that all test groups were insulin resistant; alanine aminotransferase (ALT) and asparatate aminotransferase (AST) activity values in group D significantly increased compared to other groups while its plasma glucose and insulin values showed a significant decrease in comparison to other test groups.

Conclusion: It seems that repeated morphine administration can affect liver function test (LFT) and fasting Insulin resistance index (FIRI) in fructose- fed male rats.

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