The Effect of Aerobic Exercise with and without Quercetin Supplementation on Rat’s Knee Osteoarthritis

Mohammad  Fallah-Mohammadi; Hassan Daneshmand; Akbar Hajizadeh-Moghaddam; S. Hosein Mirkarimpur

Zahedan Journal of Research in Medical Sciences

The Official Journal of Zahedan University of Medical Sciences

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The Effect of Aerobic Exercise with and without Quercetin Supplementation on Rat’s Knee Osteoarthritis

Author(s):

Mohammad Fallah-Mohammadi^1,*,

Hassan Daneshmand²,

Akbar Hajizadeh-Moghaddam³,

S. Hosein Mirkarimpur⁴

1Traumatology and Corrective Exercises, School of Physical Education and Sport Sciences, Guilan University, Rasht, Iran

2Department of Sport Traumatology and Corrective Exercises, School of Physical Education andSport Sciences, Guilan University , Rasht, Iran

3Department of Biology, School of Biology, Mazand aran University , Babolsar, Iran

4Department of Sport Traumatology and Corrective Exercises, School of Physical Education and Sport Sciences, Tehran University, Tehran, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 16, issue 2; 58-63

Published online:Jan 22, 2013

Article type:Research Article

Received:Feb 17, 2012

Accepted:May 20, 2012

How to Cite: Mohammad Fallah-MohammadiHassan DaneshmandAkbar Hajizadeh-MoghaddamS. Hosein MirkarimpurThe Effect of Aerobic Exercise with and without Quercetin Supplementation on Rat’s Knee Osteoarthritis.Zahedan J Res Med Sci.16(2):58-63.

Abstract

Background: Osteoarthritis is the commonest form of arthritis and is considered to be one out of ten major causes of disability in the world. The objective of present study was to investigate the effect of treadmill exercise alone and in combination with quercetin supplementation on male rats’ knee osteoarthritis.

Materials and Methods: Thirty male Wistar rats (weight of 173±1 g, 8-weeks old) were randomly divided into 5 experimental groups (N=6): intact control, MIA only, training, quercetin, training plus quercetin. The Osteoarthritis model was induced by intra-articular injection of monosodium iodoacetate (MIA). Subjects then followed a moderate-intensity exercise program and quercetin supplementation for 28 days. Rats were killed after 28 days and histological assessment has been performed on their knee joints. One-way ANOVA (p<0.05) and post-hoc Tukey test was used for the statistical analysis.

Results: Histological assessment including 1- Depth Ratio of Lesions (p=0.001), 2- Total Degeneration Width (p=0.001) and 3- Significant Degeneration Width (p=0.001) demonstrated a beneficial influence of moderate exercise combined with quercetin supplementation group, but this influence was not superior to the moderate exercise alone group.

Conclusion: This study shows that a moderate exercise program and quercetin supplementation, either alone or in combination, exert a beneficial influence on rats’ knee osteoarthritis. But it appears that moderate exercise alone has more effectiveness.

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