Impact of Thyroid Dysfunction on An tioxidant Capacity, Superoxide Dismutase  and Catalase Activity

Saeed  Naazeri; Mosayeb Rostamian; Mehdi  Hedayati

Zahedan Journal of Research in Medical Sciences

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Impact of Thyroid Dysfunction on An tioxidant Capacity, Superoxide Dismutase and Catalase Activity

Author(s):

Saeed Naazeri¹,

Mosayeb Rostamian²,

Mehdi Hedayati^3,*

1Tehran, Iran

2Department of Biotechnology and Biochemistry , Pasteur Institute of Iran, Tehran, Iran

3Cellular and Molecular Endocrine Research Ce nter, Institute for Endocrine Sciences, Shah id Beheshti University of Medical Sciences, Tehran , Iran

Zahedan Journal of Research in Medical Sciences:Vol. 16, issue 1; 51-54

Published online:Jun 02, 2013

Article type:Research Article

Received:Jul 10, 2012

Accepted:Oct 10, 2012

How to Cite:Saeed NaazeriMosayeb RostamianMehdi HedayatiImpact of Thyroid Dysfunction on An tioxidant Capacity, Superoxide Dismutase and Catalase Activity.Zahedan J Res Med Sci.16(1):51-54.

Abstract

Background: In hypothyroidism and hyperthyroidism, disturbance of oxidant/antioxidant balance leads to reactive oxygen species (ROS) generation. The aim of this study is assaying total antioxidant capacity and superoxide dismutase and catalase activities in patients with hypo-and hyperthyroidism in order to control the progression of its pathology and health care.

Patients and Methods: This case-control study was performed on 85 patients with hypothyroidism, 66 patients with hyperthyroidism and 74 normal individuals as control that referred to the clinic of the Research Institute for Endocrine Sciences of Shahid-Beheshti University in year 2010. Serum enzymatic activity of catalase, superoxide dismutase and total antioxidant capacity was measured in the fasting state. Data was described as mean±SD and data means of the two groups was compared by independent t-test. Data was analyzed by SPSS-18 application.

Results: The total antioxidant capacity in individuals with hyperthyroidism decreased compared to healthy controls, but individuals with hypothyroidism compared to the healthy control group showed no significant difference. Catalase and superoxide dismutase activity in hypo-and hyperthyroidism were significantly increased compared with healthy controls (p=0.005).

Conclusions: Decreasing of antioxidant capacity in hyperthyroid patients is probably because of increased production of free radicals. There was not observed significant difference in total antioxidant capacity in hypothyroid patients. Also in hypo-and hyperthyroidism patients, increasing of enzymes activity is probably due to increasing of the production of ROS.

Keywords

Hyperthyroidism

Hypothyroidism

Total Antioxidant Capacity

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