Study on the Serum Titer of Anti-HBs Antibody of the Vaccinated Staffs of a Hospital in Three Consecutive Years

Mehdi Mohsenzade; Aliyar Pirouzi; Mohammad Jafari; Mohammad Azadi; Sareh Raeiszadeh-Jahromi; Rouhi Afkari

Zahedan Journal of Research in Medical Sciences

The Official Journal of Zahedan University of Medical Sciences

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Study on the Serum Titer of Anti-HBs Antibody of the Vaccinated Staffs of a Hospital in Three Consecutive Years

Author(s):

Mehdi Mohsenzade¹,

Aliyar Pirouzi¹,

Mohammad Jafari¹,

Mohammad Azadi¹,

Sareh Raeiszadeh-Jahromi²,

Rouhi Afkari^1,*

1Gerash Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

2Department of Studies in Zoology, University of Mysore, Mysore, India

Zahedan Journal of Research in Medical Sciences:Vol. 15, issue 12; e4339

Published online:May 12, 2013

Article type:Research Article

Received:Jul 16, 2012

Accepted:Oct 05, 2012

How to Cite:Mehdi MohsenzadeAliyar PirouziMohammad JafariMohammad AzadiSareh Raeiszadeh-JahromiRouhi Afkariet al.Study on the Serum Titer of Anti-HBs Antibody of the Vaccinated Staffs of a Hospital in Three Consecutive Years.Zahedan J Res Med Sci.15(12):e4339.

Abstract

Background: Hepatitis B virus is one of the main factors causing acute and chronic hepatitis and hepatocellular carcinoma. Among others, healthcare workers are at the highest risk for exposure to hepatitis B virus. Vaccination against hepatitis B virus is one of the protective strategies but anti-HBs titer will be reduced in the sera of vaccinated people after some time. The aim of this study was to determine the titer of anti-HBs in the sera of vaccinated medical staffs in three consecutive years since administration of the last dose of hepatitis B vaccine.

Materials and Methods: This study was carried out on 90 Omidvar Hospital (Lar, Iran) medical staffs that had passed 3-4 months since the administration of the last dose of hepatitis B vaccine. All sera samples were tested for anti-HBs in an ELISA method. Finally, statistical analysis was performed using SPSS-16 software.

Results: This study was conducted in duration of 3 consecutive years on 90 medical staffs including 14.44% lab technicians, 10% obstetricians, 43.35% nurses, 6.665% specialists, 5.55% general practitioners and 20% maid staffs. While HBs Ab titer was measured as 87.7% (>100 mIU/ml) in the first year elapsed since the last dose of hepatitis B vaccination, it had been decreased to 55.4% after 3 years.

Conclusion: The results showed that re-vaccination of the medical staffs is quite necessary as anti-HBs titer had been decreased after 3 years and the desired immune response was seen only in 55.4% of the medical staffs.

Keywords

Hepatitis B virus

HBs antibody

Hepatitis B vaccine

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