Effects of drug therapy of visceral leishmaniasis on serum level of IFN-γ, IL-10 and IL-12 in visceral leishmaniasis patients

abolfazl khoshdel; abdolvahab alborzi; manoochehr Rasouli; elham Taheri

Zahedan Journal of Research in Medical Sciences

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Effects of drug therapy of visceral leishmaniasis on serum level of IFN-γ, IL-10 and IL-12 in visceral leishmaniasis patients

Author(s):

abolfazl khoshdel^1,*,

abdolvahab alborzi²,

manoochehr Rasouli²,

elham Taheri³

1Dept of Pediatrics, Shahrekord University of Medical Sciences and Health Services, Shahrekord. Iran

2Professor Alborzi Clinical Microbiology Research Center, Namazi Hospital, Shiraz University of Medical Sciences and Health Services, Shiraz, Iran

3General Physician, Shaharekord University of Medical Sciences and Health Services, Shahrekord, Iran.

Zahedan Journal of Research in Medical Sciences:Vol. 10, issue 1; e92278

Published online:Mar 03, 2008

Article type:Research Article

Received:Feb 11, 2008

Accepted:Jun 24, 2008

How to Cite:abolfazl khoshdelabdolvahab alborzimanoochehr Rasoulielham TaheriEffects of drug therapy of visceral leishmaniasis on serum level of IFN-γ, IL-10 and IL-12 in visceral leishmaniasis patients.Zahedan J Res Med Sci.10(1):e92278.

Abstract

Background: Leishmaniosis has remained a serious public health problem in several parts of the developing world. Effective prophylacyic measurements are hampered by imprecise understanding of different aspects of the disease, including its immunoregulation. A better understanding of immunoregulation in human visceral leishmaniosis may be useful both for designing and evaluating immunoprophylaxis. Materials and Methods: This before-after interventional study investigated immunoregulatory mechanisms among 32 patients with visceral leishmaniasis in Shiraz (Iran) in 2007. The plasma cytokine (IFN-gamma, IL-10 and IL-12) levels of participants were measured before, during active disease and at different periods up to 2 months after treatment. Results: Elevated plasma levels of IFN-γ, IL-10 and IL-12 which were observed during active disease, decreased significantly after treatment. The main candidate for blunting IFN- γ activity seems to be IL-10, since the level of this cytokine which highly elevated in plasma decreased sharply after treatment (Before treatment 88.3±77.5, after treatment 25±18.3, 2months after treatment 517±1.9). difference between samples was significant (P<0/05) Discussion: Results suggest that IFN- γ and IL-10 are the molecules most likely involved in determining fate of the disease. After treatment, there is a long delay before the immune profile returns to its normal level which precludes using plasma cytokine levels as criteria for certain cure diagnosis of the disease.

Keywords

visceral leishmaniosis

Cytokine

IFN-γ

IL-10

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