Effect of Urtica Dioica Extract on Histological and Histometrical Changes of Testis of Hamster after Testosteron Administration

Hassan Morovvati; Hossein  Najafzadeh; Khodabakhsh Rashidi

Zahedan Journal of Research in Medical Sciences

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Effect of Urtica Dioica Extract on Histological and Histometrical Changes of Testis of Hamster after Testosteron Administration

Author(s):

Hassan Morovvati¹,

Hossein Najafzadeh^2,*,

Khodabakhsh Rashidi³

1Department of Veterinary Histology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran

2Department of Veterinary Histology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran

3Department of Medical Pharmacology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 15, issue 11; e92775

Published online:May 20, 2013

Article type:Research Article

Received:Oct 21, 2012

Accepted:Feb 16, 2013

How to Cite:Hassan MorovvatiHossein NajafzadehKhodabakhsh RashidiEffect of Urtica Dioica Extract on Histological and Histometrical Changes of Testis of Hamster after Testosteron Administration.Zahedan J Res Med Sci.15(11):e92775.

Abstract

Background: Hyperactivity of testosterone is one cause of infertility and its incorrect use can produces reproductive disorders. Nettle (Urtica dioica) has antiandrogenic effect and may antagonized effect of testosterone. In present study structure of testes of golden hamster was evaluated after testosterone and extract.
Materials and Methods: In this experimental and animal modeling study, twenty male mature hamsters were divided to 4 groups, group 1 was control, group 2 received testosterone at dose 3 mg/kg subcutaneously, group 3 received nettle extract dose 30 mg/kg orally and group 4 received testosterone and nettle for 30 days daily. The hamsters were euthanized and testes were removed and detected macroscopic parameters (weight, height, wide and volume) and fixed with formalin. The samples were sectioned and colored with H & E.
Results: The volume, weight, length and wide of testes was at least in testosterone group and statistically was lesser than control and testosterone -nettle group (p<0.05), but did not the height epithelium of seminifer tubules, compact of spermatogenic cells and number of serotolli cells in testosterone group was lesser than control group significantly (p<0.05).
Conclusion: The nettle extract decreased histological changes of testes by testosterone and improved its structure.

Keywords

Testes tissue

Testosterone

Urtica dioica extract

Hamster

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