The Comparative Effects of Aqueous Extract of Walnut (Juglans regia) Leaf and Glibenclamide on Serum Glucose Levels of Alloxan-Induced Diabetic Rats

mahdi noureddini; Fatameh Rezaee-Joshogani

Zahedan Journal of Research in Medical Sciences

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The Comparative Effects of Aqueous Extract of Walnut (Juglans regia) Leaf and Glibenclamide on Serum Glucose Levels of Alloxan-Induced Diabetic Rats

Author(s):

mahdi noureddini¹,

Fatameh Rezaee-Joshogani^2,*

1PhD in Physiology, Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran

2MSc in Animal Biology, North Khorasan University of Medical Sciences, Bojnurd, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 15, issue 11; e92779

Published online:Apr 25, 2013

Article type:Research Article

Received:Feb 11, 2012

Accepted:May 18, 2012

How to Cite:mahdi noureddiniFatameh Rezaee-JoshoganiThe Comparative Effects of Aqueous Extract of Walnut (Juglans regia) Leaf and Glibenclamide on Serum Glucose Levels of Alloxan-Induced Diabetic Rats.Zahedan J Res Med Sci.15(11):e92779.

Abstract

Background: The use of medicinal plants for lowering glucose level in diabetic patients is
of clinical importance. The present study investigated the effect of a 30-day oral
administration of aqueous extract of walnut leaf and glibenclamide on blood glucose level
in normal and diabetic rats.
Materials and Methods: In this experimental study, 120 male rats (Sprague-Dawley, 150-
250 g) were divided into 12 equal groups as following: normal control group, normal
group receiving glibenclamide (4 mg/kg), three normal groups receiving the extract doses
of 50, 10, and 150 mg/kg, alloxan-diabetic control group (170 mg/kg), diabetic group
receiving glibenclamide (4 mg/kg), and five diabetic groups receiving the extract in doses
of 10, 50, 150, 300, and 500 mg/day by oral administration for 30 days. Glucose levels of
the fasting rats were measured at 0, 7th, 14th, 21st, and 30th days using glucometer.
Results: Administration of all doses and over 10 mg/kg significantly lowered the blood
glucose level in normal rat and diabetic rats, compared with dose and duration-dependent
control groups. This effect was higher for doses of 50 and 150 mg/kg in normal rats and
for doses of 300 and 500 mg/kg in diabetic rats, similar to glibenclamide (4 mg/kg).
Conclusion: Walnut leaf aqueous extract, depending on dose and duration, has dose and
duration dependent declining effect on glucose level in normal rats and antihyperglycemic
effect on diabetic rats, with a few side effects. This effect at some doses is greater or equal
to that of glibenclamide.

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