Effects of Echinacea Purpurea onWound Healing after Arsenic Induced Skin Necrosis

Annahita  Rezaie; Hossein  Najafzadeh; Mahdi Poormahdi-Broojeni; Babak Mohammadian; Marzieh Heidari

Zahedan Journal of Research in Medical Sciences

The Official Journal of Zahedan University of Medical Sciences

Current Issue All Issues In Press Articles Accepted Manuscripts Search

Journal Information Boards and Committees Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Contact Us Support Reviewer and AE Registration Form

APC

Authors Guide Submit Manuscript

Effects of Echinacea Purpurea onWound Healing after Arsenic Induced Skin Necrosis

Author(s):

Annahita Rezaie^1,*,

Hossein Najafzadeh²,

Mahdi Poormahdi-Broojeni³,

Babak Mohammadian¹,

Marzieh Heidari⁴

1Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran

2Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran

3Department of Food Hygiene, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran

4Graduated in Veterinary Medicine, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 15, issue 11; e92787

Published online:Jan 26, 2013

Article type:Research Article

Received:Jan 19, 2012

Accepted:Jul 03, 2012

How to Cite:Annahita RezaieHossein NajafzadehMahdi Poormahdi-BroojeniBabak MohammadianMarzieh HeidariEffects of Echinacea Purpurea onWound Healing after Arsenic Induced Skin Necrosis.Zahedan J Res Med Sci.15(11):e92787.

Abstract

Background: Evaluation of healing effects of Echinacea extract in Arsenic induced dermal necrosis in rat is the objective of this study.
Materials and Methods: In this experimental study 20 male Wistar rats were divided to 2 groups. Dermal necrosis was induced by subcutaneously arsenic injection (4mg/kg) for 10 days. In group 2, after arsenic receiving, Echinacea were injected intraperitoneally (400mg/kg). After last day of injection, rats were euthanizes and pathologic samples were collected from dermal ulcers.
Results: Histopathologic results revealed necrosis of different dermal layers in arsenic group. There were inflammatory exudates instead of impaired structures. In group 2, there were granulation tissue with high cellularity and new vessels.
Conclusion: According to this research findings arsenic can induce dermal necrosis which is a good animal model for dermatologic researches and also Echinacea has healing effects and can protect and limit the Arsenic effects.

Keywords

Fulltext

The full text of this article is available on the PDF file.

References

1.
The References of this article are available on the PDF file.

comments