The Cytoprotective Effects of Morus Alba Leaves in Cultured Fetus Fibroblast Cells against Hyperglycemia

Mohammadreza Shams-Ardekani; Abbas Barin; Naiema Vakili-Saatloo; parisa sadighara

Zahedan Journal of Research in Medical Sciences

The Official Journal of Zahedan University of Medical Sciences

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The Cytoprotective Effects of Morus Alba Leaves in Cultured Fetus Fibroblast Cells against Hyperglycemia

Author(s):

Mohammadreza Shams-Ardekani¹,

Abbas Barin²,

Naiema Vakili-Saatloo³,

parisa sadighara^3,*

1Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran

2Department of Clinical Pathology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran

3Department of Environmental Health, Food Safety Division, School of Public Health, Tehran University of Medical Science, Tehran, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 15, issue 11; e92806

Published online:May 28, 2013

Article type:Research Article

Received:Aug 19, 2012

Accepted:Nov 14, 2012

How to Cite:Mohammadreza Shams-ArdekaniAbbas BarinNaiema Vakili-Saatlooparisa sadigharaThe Cytoprotective Effects of Morus Alba Leaves in Cultured Fetus Fibroblast Cells against Hyperglycemia.Zahedan J Res Med Sci.15(11):e92806.

Abstract

Background : Diabetes is a chronic disease characterized by high blood glucose levels. Medicinal plants have useful source of hypoglycemic compounds and play important role in preventing the progress of this disease. Morus alba leaves is natural therapeutic agent shown hypoglycemic effects. In this study, the protective effects of alcoholic extract Morus alba leaves on fetus fibroblast cells under hyperglycemic condition were assessed.
Materials and Methods : In this experimental study the cells were treated with six different concentrations of extracts. The nontoxic concentration of plant extract was measured with MTT assay in fetus fibroblast cells. Then, the fetus fibroblast cells were incubated with high dose of glucose and plant extract at concentrations of 1000 ppm. DNA synthesis, as marker of cell proliferation was determined.
Results : There were significant changes in cell proliferation in treated group with plant extract. Morus alba leaves could cause cell attachment and proliferation. The attachment of cells to culture plates has been shown to be affected by plant extract.
Conclusion : The data obtained from this study approved that Morus alba leaves has cytoprotective effects against hyperglycemia.

Keywords

Morus alba

Cytoprotective

Hyperglycemia

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