Effect of Pistacia Atlantica Extract on Glutathione Peroxidase Tissue Levels and Total Oxidative Capacity of Liver and Plasma Lipid Profile of Rats

Parvin  Farzanegi; Monireh Mousavi; Abbass  Ghanbari-Niaki

Zahedan Journal of Research in Medical Sciences

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Effect of Pistacia Atlantica Extract on Glutathione Peroxidase Tissue Levels and Total Oxidative Capacity of Liver and Plasma Lipid Profile of Rats

Author(s):

Parvin Farzanegi^1,*,

Monireh Mousavi¹,

Abbass Ghanbari-Niaki²

1Department of Exercise Physiology, Faculty of Humanities, Islamic Azad University Sari Branch, Sari, Iran

2Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, University of Mazandaran, Babolsar, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 15, issue 11; e92809

Published online:Feb 10, 2013

Article type:Research Article

Received:Jan 25, 2012

Accepted:May 20, 2012

How to Cite:Parvin FarzanegiMonireh MousaviAbbass Ghanbari-NiakiEffect of Pistacia Atlantica Extract on Glutathione Peroxidase Tissue Levels and Total Oxidative Capacity of Liver and Plasma Lipid Profile of Rats.Zahedan J Res Med Sci.15(11):e92809.

Abstract

Background : Exercise causes increased oxygen consumption, leaving cells exposed to oxidative stress. Antioxidants may have a protective effect by inhibiting lipid peroxidation. Thus, this study aims to examine the effect of Pistacia atlantica extract on glutathione peroxidase levels and total oxidative capacity of liver and plasma lipid profile of rats.
Materials and Methods : In this experimental study, 28 female rats’ weight 155.8±2.7 grams were randomly and equally divided into 4 groups of exercise-saline, control-saline, exercise-mastic, and control-mastic. The exercise groups exercised for 8 weeks (5 days per week, 60 minutes daily, 25 meters per minute, on a zero degree slope). The rats received equal volumes of mastic and saline orally for 4 weeks. Blood and tissue samples were taken 72 hours after the last exercise session. Data were analyzed using one-way variance analysis (ANOVA).
Results : Consumption of Pistacia atlantica extract together with endurance exercising for 8 weeks did not significantly affect glutathione peroxidase concentration, total oxidative capacity, LDL, triglyceride, or cholesterol, but significantly reduced HDL (p=0.002).
Conclusion : Results showed that antioxidant and lipid profile levels were not affected by consumption of supplements and endurance exercising. However, further studies are required to assess the long term effects of this herbal extract.

Keywords

Glutathione peroxidase

Total oxidative capacity

Lipid profile

Pistacia atlantica

Endurance exercise

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