Association of DD Genotype of Insertion/Deletion Polymorphism of Angiotensin-Converting Enzyme Gene with Systemic Lupus Erythematosus and Lupus Nephropathy

Saeedeh  Salimi; Anoosh Naghavi; Zahra Zakeri; Sima  Nabizadeh; Farzaneh Farajian-mashhadi; Mahnaz Sandoughi

Zahedan Journal of Research in Medical Sciences

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Association of DD Genotype of Insertion/Deletion Polymorphism of Angiotensin-Converting Enzyme Gene with Systemic Lupus Erythematosus and Lupus Nephropathy

Author(s):

Saeedeh Salimi¹,

Anoosh Naghavi¹,

Zahra Zakeri²,

Sima Nabizadeh³,

Farzaneh Farajian-mashhadi⁴,

Mahnaz Sandoughi^2,*

1Department of Clinical Biochemistry, Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

2Department of Internal Medicine, Clinical Research Development Center, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

3Department of English, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

4Department of Pharmacology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 15, issue 10; e92822

Published online:Mar 12, 2013

Article type:Research Article

Received:Oct 28, 2012

Accepted:Jan 15, 2013

How to Cite:Saeedeh SalimiAnoosh NaghaviZahra ZakeriSima NabizadehFarzaneh Farajian-mashhadiMahnaz Sandoughiet al.Association of DD Genotype of Insertion/Deletion Polymorphism of Angiotensin-Converting Enzyme Gene with Systemic Lupus Erythematosus and Lupus Nephropathy.Zahedan J Res Med Sci.15(10):e92822.

Abstract

background : Systemic lupus erythematosus (SLE) is a multisystem disease with unknown etiology. We hypothesized that insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) gene may influence the development and/or progression of SLE and lupus nephritis.
Materials and Methods : In a crass sectional case-control study, genomic DNA from 106 SLE patients and 103 healthy controls matched for sex, age, and ethnicity, were genotyped for the (I/D) polymorphism of ACE gene by polymerase chain reaction (PCR). Comparison of quantitative variants between two groups was assessed by student t-test and association between qualitative variables was analyzed by the chi-square or Fisher exact tests.
Results : The frequency of DD genotype in SLE patients was significantly higher than control group (25.5 % vs. 14 %), and the risk of SLE was 2.2 times greater in subjects with DD genotype than the individual by DI and II genotypes (OR, 2.2 [95% CI, 1.1 to 4.4] p=0.023). The distribution of D allele in SLE patients was significantly higher (p=0.021) compare to controls (47 and 36.4, respectively). The Risk of nephropathy in SLE patients with DD genotype was three times more than other genotypes (OR), 3 [95% CI, 1.1 to 8] p=0.027].
Conclusion: This study demonstrated that ACE DD genotype acts as a risk factor on SLE and Lupus nephropathy in an Iranian population.

Keywords

Systemic lupus erythematosus

Lupus nephropathy

Angiotensin-converting enzyme

Polymorphism

Iran

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