Effect of Amonium Vanadate Nano-Particles on Experimental Diabetes and Biochemical Factors in Male Spargue-Dawly Rats

Negar Keyshams; S. Reza Fatemi; Hossein  Najafzadeh; Ali Ashrafi

Zahedan Journal of Research in Medical Sciences

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Effect of Amonium Vanadate Nano-Particles on Experimental Diabetes and Biochemical Factors in Male Spargue-Dawly Rats

Author(s):

Negar Keyshams¹,

S. Reza Fatemi²,

Hossein Najafzadeh^3,*,

Ali Ashrafi⁴

1Department of Physiology, Faculty of Sciences, Shahid Chamran University, Ahvaz, Iran

2Department of Physiology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran

3Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran

4Department of Materials, Faculty of Engineering, Shahid Chamran University, Ahvaz, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 15, issue 10; e92836

Published online:Mar 12, 2013

Article type:Research Article

Received:Jun 14, 2012

Accepted:Jul 11, 2012

How to Cite:Negar KeyshamsS. Reza FatemiHossein NajafzadehAli AshrafiEffect of Amonium Vanadate Nano-Particles on Experimental Diabetes and Biochemical Factors in Male Spargue-Dawly Rats.Zahedan J Res Med Sci.15(10):e92836.

Abstract

Background : Vanadium compounds have antidiabetic, but there is no study about the antidiabetic effects f ammonium monovanadate nono-particles. In this study, antidiabetic effect of ammonium monovanadate was compared with its nonoparticles.
Materials and Methods : In this experimental and animal modeling study, 42 male Sprague Dawley rats were divided in 6 groups (each group 7 rats). Diabetes was induced by IP injection of 60 mg/kg streptozicin to five groups. One normal group and one diabetic group were kept without treatment as control groups. Other diabetic rats were treated with nonovanadate 25 mg/kg (NV25), ordinary vanadate 25 mg/kg (V25), nonovanadate 15 mg/kg (NV15) and water ordinary vanadate 25 mg/kg (WV25) groups for 10 days by gavage. Heparinized blood was collected at days 11 and 21 and centrifuged to separate plasma. Glycosylated hemoglobin, insulin, triglyceride (TG), total cholesterol (TC), HDL-c and LDL-c were measured at both time and compared between groups.
Results : All treatment except in V25 decreased glycemia, but insulin increased only in NV25 group (p<0.05). All treatment decreased TG, TC and LDL-c significantly (p<0.001).
Conclusion : Ammonium mono vanadate nonoparticle has better effects than ordinary ammonium mono vanadate on some biochemical factors in experimental diabetes.

Keywords

Ammonium mono vanadate

nanoparticle

Diabetes

Rat

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