Evaluation of Left Ventricular Systolic Function after Cardiac Resynchronization Therapy in Heart Failure Patients

Zagross Hassaniani; Jalal Kheirkhah; Hassan Moladoust; Hamidreza Bonakdar; Mohammad Assadian-Rad; Anoosh Barzigar; fardin  Mirbolouk; Bijan Shad; Manouchehr Azarpira; Vahid Toulabi

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Evaluation of Left Ventricular Systolic Function after Cardiac Resynchronization Therapy in Heart Failure Patients

Author(s):

Zagross Hassaniani¹,

Jalal Kheirkhah^1,*,

Hassan Moladoust¹,

Hamidreza Bonakdar¹,

Mohammad Assadian-Rad¹,

Anoosh Barzigar¹,

fardin Mirbolouk¹,

Bijan Shad¹,

Manouchehr Azarpira¹,

Vahid Toulabi¹

1Cardiovascular Research Center, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 15, issue 9; e92847

Published online:Jul 20, 2013

Article type:Research Article

Received:Jun 14, 2013

Accepted:May 26, 2013

How to Cite:Zagross HassanianiJalal KheirkhahHassan MoladoustHamidreza BonakdarMohammad Assadian-RadAnoosh Barzigarfardin MirboloukBijan ShadManouchehr AzarpiraVahid Toulabiet al.Evaluation of Left Ventricular Systolic Function after Cardiac Resynchronization Therapy in Heart Failure Patients.Zahedan J Res Med Sci.15(9):e92847.

Abstract

Background : Cardiac resynchronization therapy (CRT) has introduced as new treatment strategy in heart failure (HF) patients and some of its effects have been investigated. The aim of this study was to study the effectiveness of CRT in the improvement of left ventricular systolic function indicated by left ventricular ejection fraction (LVEF) in HF patients.
Materials and Methods : In our prospective study 22 HF patients with NYHA class III and above, QRS duration>120 ms and EF (ejection fraction) ≤35% who were candidates for CRT enrolled. Patients were evaluated for NYHA class, QRS width, left ventricular end-systolic volume (LVESV), left ventricular end-diastolic volume (LVEDV) and LVEF before and two months after the CRT procedure. Paired-t test analysis used to compare the before and post-CRT data statistically.
Results : Initial evaluation showed that all of the patients were in NYHA class III before CRT. Two months after CRT, all of the patients improved their NYHA class in a way that 18 patients (82%) were in NYHA class I and the other 4 (18%) were in NYHA class II. The mean (SD) QRS width decreased significantly after biventricular (BiV) pacing (p<0.001). Also a significant decrease in LVESV, LVEDV and increase in LVEF was shown in HF patients after CRT (p<0.001).
Conclusion : The present study showed the efficacy of CRT in improvement of LVEF in HF patients with wide QRS after two months from CRT.

Keywords

Cardiac resynchronization

therapy

Ventricular ejection fraction

Heart failure

Echocardiography

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