Comparison Between the Effects of the Alcholic Extract of Mellissia Officinalis and Atorvastatin on Serum Levels of Thyroid Hormones in Hypercholesterolemic Male Rats

Ali Zarei; Saeed  Changizi Ashtiyani; Mansour Sokhandani; Azam Rezaei; Saeed Zaheiri; Soheila Taheri

Zahedan Journal of Research in Medical Sciences

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Comparison Between the Effects of the Alcholic Extract of Mellissia Officinalis and Atorvastatin on Serum Levels of Thyroid Hormones in Hypercholesterolemic Male Rats

Author(s):

Ali Zarei¹,

Saeed Changizi Ashtiyani^2,*,

Mansour Sokhandani³,

Azam Rezaei⁴,

Saeed Zaheiri⁵,

Soheila Taheri⁶

1Department of Physiology, Science and Research Branch, Azad University of Damghan, Damghan, Iran

2Department of Physiology, Arak University of Medical Sciences, Arak, Iran

3Department of Nursing, Shiraz University of Medical Sciences, Shiraz, Iran

4Department of Physiology, Azad University of Arsanjan, Arsanjan, Iran

5Department of Biology, Payam-e-Noor University, Tehran, Iran

6Staff of Education Development Center, Arak University of Medical Sciences, Arak, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 15, issue 8; e92894

Published online:Dec 30, 2012

Article type:Research Article

Received:May 09, 2012

Accepted:Oct 14, 2012

How to Cite:Ali ZareiSaeed Changizi AshtiyaniMansour SokhandaniAzam RezaeiSaeed ZaheiriSoheila Taheriet al.Comparison Between the Effects of the Alcholic Extract of Mellissia Officinalis and Atorvastatin on Serum Levels of Thyroid Hormones in Hypercholesterolemic Male Rats.Zahedan J Res Med Sci.15(8):e92894.

Abstract

Background: Consumption of unsaturated fats reduces the serum level of lipids and leptin.
Thyroid hormones and leptin play pivotal roles in metabolism and their amounts are interrelated.
This study was done to compare the effects of Mellissia officinalis extract and
atorvastatin on the serum levels of thyroid hormones in hypercholesterolemia rats.
Materials and Methods: Consumption of unsaturated fats reduces the serum level of lipids
and leptin. Thyroid hormones and leptin play pivotal roles in metabolism and their
amounts are inter-related. This study was done to compare the effects of Mellissia
officinalis extract and atorvastatin on the serum levels of thyroid hormones in
hypercholesterolemia rats.
Results: The results showed that in experimental groups receiving the plant extract and
atorvastatin, the concentration of thyroid hormones increased, whereas the amount of the
thyroid-stimulating hormone showed a significant decrease (p<0.05).
Conclusion: Mellissia officinalis extract decreases TSH but it increases T3 and T4. Further
studies are required for applying this extract to the treatment of hyperthyroidism.

Keywords

Atorvastatin

Hypercholesterolemia

Mellissia officinalis

Thyroid

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References

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