Evaluation of Antifungal Activity of Methanol Extract of Acacia (Anagalis Arvensis) Leaves and Nystatin against Candida Albicans in Vitro

Mohammad Reza  Majid Khoshkholgh-Pahlaviani; Ali Reza Massiha; Khosro Issazadeh; Siroos Bidarigh; Masoud Giahi; Maryam Ramtin

Zahedan Journal of Research in Medical Sciences

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Evaluation of Antifungal Activity of Methanol Extract of Acacia (Anagalis Arvensis) Leaves and Nystatin against Candida Albicans in Vitro

Author(s):

Mohammad Reza Majid Khoshkholgh-Pahlaviani^1,*,

Ali Reza Massiha²,

Khosro Issazadeh³,

Siroos Bidarigh⁴,

Masoud Giahi⁵,

Maryam Ramtin⁶

1Department of Clinical Bacteriology, Faculty of Basic Sciences, Islamic Azad University of Lahijan Branch, Lahijan, Iran

2Department of Biotechnology, Faculty of Basic Sciences, Islamic Azad University of Lahijan Branch, Lahijan, Iran

3Department of Microbiology, Faculty of Basic Sciences, Islamic Azad University of Lahijan Branch, Lahijan, Iran

4Department of Agriculture, Faculty of Natural Resource, Islamic Azad University of Lahijan Branch, Lahijan, Iran

5Department of Chemistry, Faculty of Basic Sciences, Islamic Azad University of Lahijan Branch, Lahijan, Iran

6Department of Microbiology, Member of Young Researchers Club, Islamic Azad University of Lahijan, Lahijan, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 15, issue 8; e92906

Published online:Dec 30, 2012

Article type:Research Article

Received:Apr 20, 2011

Accepted:Sep 07, 2011

How to Cite:Mohammad Reza Majid Khoshkholgh-PahlavianiAli Reza MassihaKhosro IssazadehSiroos BidarighMasoud GiahiMaryam Ramtinet al.Evaluation of Antifungal Activity of Methanol Extract of Acacia (Anagalis Arvensis) Leaves and Nystatin against Candida Albicans in Vitro.Zahedan J Res Med Sci.15(8):e92906.

Abstract

Background: Anagalis is the name of Scarlet Pimpernel, with about 20 to 25 species of flowering plants in the family Myrsinaceae. The common variety (A. arvensis) is a low-growing annual plant found in Europe, Asia and North America. In this Investigation, the inhibitory effects of methanol extract of Anagalis arvensis leaves and drug nystatin on clinical isolates and standard strain of Candida albicans (14053 PTCC) isolated from patients with vulvovaginal candidiasis were studied.
Materials and Methods: In the laboratory study of 45 clinical isolates of Candida albicans was used and inhibitory effects of the extract were evaluated using by serial dilution Method. Chemical compounds of A. arvensis extract including alkaloids, glycosides, phenolic compounds, Terpenoids and amino acids were identified
Results: The results showed that the minimum inhibitory concentration (MIC) nystatin against clinical isolates and standard strain of Candida albicans were similar and drug nystatin revealed the better MIC against standard strain and clinical isolates of C. albicans. Methanol extract of A. arvensis were inhibitory on standard strain and clinical isolates of C. albicans. The minimum inhibitory concentration of extract in comparison with the drug nystatin was less while the composition of the growth inhibitory concentration was greater than drug solely
.
Conclusion: This study indicated that the antimicrobial activity of this plant extract was considerable compared to drug nystatin and it demonstrate a basis for further research to isolate the active components in a variety of microbial strains
.
.

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