The Effect of Oxidative Stress and Antioxidants on Men Fertility

Abolfazl Akbari; gholamali jelodar

Zahedan Journal of Research in Medical Sciences

The Official Journal of Zahedan University of Medical Sciences

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The Effect of Oxidative Stress and Antioxidants on Men Fertility

Author(s):

Abolfazl Akbari¹,

gholamali jelodar^1,*

1Department of Physiology, Faculty of Veterinary, Shiraz University of Medical Sciences, Shiraz, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 15, issue 7; e92918

Published online:Jan 07, 2013

Article type:Review Article

Received:Oct 11, 2011

Accepted:Dec 22, 2011

How to Cite:Abolfazl Akbarigholamali jelodarThe Effect of Oxidative Stress and Antioxidants on Men Fertility.Zahedan J Res Med Sci.15(7):e92918.

Abstract

Background: Various factors affects men fertility and oxidative stress as an important factor which affects fertility has recently got great concern. Oxidative stress refers to conditions of imbalance between productions of reactive oxygen species (ROS) and antioxidant defense mechanism. Reactive species of oxygen, free radicals and peroxide are produced in the cell when metabolism of oxygen is incomplete in the mitochondrial respiratory chain. Materials and Methods: In this review we will consider effect of oxidative stress on male fertility and the principal antioxidant defences. Results: Factors such as hypoxia, cytokines, growth factors, chemotherapy, radio frequency waves and UV radiation can increase ROS production. Oxidative stress as one of the strongest physiological factors can lead to damage of sperm and reduction of seminal plasma quality and thereby cause infertility in men. Enzymatic and non-enzymatic defences inhibit oxidant attack. The enzymatic defense include: superoxide dismutases, glutathione peroxidases, and catalase. The non-enzymatic defences include ascorbate (vitamin C) and a-tocopherol (vitamin E), beta carotene, and albumin, which neutralize free radicals. Conclusion: Oxidative stress affects male fertility through induction of lipid peroxidation, inactivation of proteins, impair of sperm motility and DNA damage.

Keywords

Infertility

Oxidative stress

Reactive oxygen species

Antioxidant

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