Materials and Methods : Male Wistar rats (250±20 g, N=40) were made diabetic by streptozotocin (60 mg/kg, subcutaneously). 72 h after injection diabetes induction was confirmed by tail vein blood glucose concentration (>300 mg/dl). Then animals were divided to five groups: diabetic control (DC), diabetic trained (DT), diabetic -vitamin D (DD), diabetic trained and vitamin D (DTD), and control (C). Animals were submitted to endurance training by treadmill and vitamin D3 treatment (twice aweek, intrapretonally) for 4 weeks. 48 h after at the end of exercise and treatment protocol, we used tail-flick to assess the effects of training and vitamin D3 on thermal pain threshold. We used one way ANOVA statistical analysis to compare differences between groups, significance level of p<0.05 was considered.
Results : Diabetic induced hyperalgesia were decreased significantly by vitamin D but not 4 weeks endurance exercise training. Concurrent effects of training and vitamin D on thermal pain threshold were not significantly higher than vitamin D effects alone.
Conclusion : It is concluded that vitamin D administration given at the time of diabetes induction may be able to restore thermal hyperalgesia. But effects of endurance exercise training needs to more investigation in diabetic rats.
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