Study of Association between Interleukin 20 Polymorphism (Rs1518108) and Chronic Hepatitis C Infection

Elham Arbabi-Aval; S. Reza Mohebbi; Fatemeh Rostami; Manizheh Habibi; Mohsen Vahedi; Shohreh Almasi; Nastaran Saeedi; Pedram Azimzadeh; Mohammad-Reza Zali

Zahedan Journal of Research in Medical Sciences

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Study of Association between Interleukin 20 Polymorphism (Rs1518108) and Chronic Hepatitis C Infection

Author(s):

Elham Arbabi-Aval¹,

S. Reza Mohebbi^1,*,

Fatemeh Rostami¹,

Manizheh Habibi¹,

Mohsen Vahedi²,

Shohreh Almasi¹,

Nastaran Saeedi³,

Pedram Azimzadeh¹,

Mohammad-Reza Zali⁴

1Department of Viral Hepatitis and Liver Diseases, Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2Department of Biostatistics and Epidemiology, Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3Department of Molecular Genetics and Cancer, Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 15, issue 7; e92927

Published online:Jan 07, 2013

Article type:Research Article

Received:Jul 10, 2011

Accepted:Oct 22, 2012

How to Cite:Elham Arbabi-AvalS. Reza MohebbiFatemeh RostamiManizheh HabibiMohsen VahediShohreh AlmasiNastaran SaeediPedram AzimzadehMohammad-Reza Zaliet al.Study of Association between Interleukin 20 Polymorphism (Rs1518108) and Chronic Hepatitis C Infection.Zahedan J Res Med Sci.15(7):e92927.

Abstract

Background : Chronic hepatitis C is a major concern for global health as it causes liver problems, cirrhosis and liver cancer. Immune factors have a determinant role in susceptibility to chronic infection or clearance of infection in body. As a defensive agent, cytokines are important factors of immune system, since they can activate immune response or inhibit virus replication directly. The aim of this study is the evaluation of interleukin 20 polymorphism (rs1518108) in hepatitis C patients.
Materials and Methods : This survey was a case–control study. By using PCR-RFLP method, 105 patients and 135 controls were studied randomly. We used SPSS-16 software for statistical analysis.
Results : A significant association was found between polymorphism (rs1518108) of interleukin 20 and hepatitis C patients (p=0.035) (OR=2.283). The incidence of hepatitics C in males was observed five times more than that one females (p=0.01) (OR=5.18). In addition, no significant association between polymorphism of genotypes and liver harms (chronic and cirrhosis) was found in this study (p=0.362).
Conclusion : Our findings show that variants of interleukin 20 polymorphism (rs1518108) in the population of the study are important factors for being affected by hepatitis C. The incidence of heterozygote allele CT was more than of homozygote genotype TT.

Keywords

Single nucleotide

polymorphism

Hepatitis C virus

Interleukin 10 and Interleukin

20

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