The Study of the Effects of Post Treatment with Rosmarinus Officinalis Aqueous Extract the First 48 Hours after Renal Ischemia/Reperfusion in Rats

Saeed Changizi-Ashtiyani; Marzieh Zohrabi; Akbar Hassanpoor; Saeed Hajihashemi; Nasser Hosseini

Zahedan Journal of Research in Medical Sciences

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The Study of the Effects of Post Treatment with Rosmarinus Officinalis Aqueous Extract the First 48 Hours after Renal Ischemia/Reperfusion in Rats

Author(s):

Saeed Changizi-Ashtiyani^1,*,

Marzieh Zohrabi²,

Akbar Hassanpoor³,

Saeed Hajihashemi¹,

Nasser Hosseini⁴

1Kidney and Blood Pressure Research Center, Arak University of Medical Sciences, Arak, Iran

2Department of Physiology, Arak University of Medical Sciences, Arak, Iran

3Department of Pathology, Arak University of Medical Sciences, Arak, Iran

4Department of Medicinal Plants, Arak University Arak, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 15, issue 6; e92930

Published online:Oct 29, 2012

Article type:Research Article

Received:Oct 26, 2011

Accepted:Dec 14, 2011

How to Cite:Saeed Changizi-AshtiyaniMarzieh ZohrabiAkbar HassanpoorSaeed HajihashemiNasser HosseiniThe Study of the Effects of Post Treatment with Rosmarinus Officinalis Aqueous Extract the First 48 Hours after Renal Ischemia/Reperfusion in Rats.Zahedan J Res Med Sci.15(6):e92930.

Abstract

Background: Acute renal failure induced by ischemia / reperfusion (I/R) causes excretory
functional disorders of nephrons. The purpose of this study is to evaluate the intake of oral
rosemary extract (gavage) on hemodynamic changes and tissue damages caused by I/R.
Materials and Methods: This study was conducted on 40 Sprague-Dawley male rats,
composed of 4 groups (n=10) including control, sham, I/R+normal saline (I/R+NS) posttreatment
and I/R+rosemary (I/R+RO) post-treatment. They were fed with 10 ml/kg of 8%
aqueous extract or vehicle as gavages during the first 48 hours after I/R. To induce I/R,
both renal artery and vein were blocked for 30 minutes followed by a reperfusion within
48 hours. Then urine and plasma samples were collected and histological study was also
conducted after removal of both kidneys. Data were analyzed by SPSS-11.5 software. The
one-way analysis of variance (ANOVA) and Duncan test were used for intergroup
comparison and p≤ 0.05 was used as the significant level. The Kruskal–Wallis multiple
comparison test was also used for doing histological analysis
Results: Comparison of renal function between two groups of (I/R+RO) and (I/R+NS),
showed a significant reduction in plasma creatinine (p=0.05), the blood urea nitrogen
(p=0.05), absolute excretion of sodium (p=0.001) and an increase in absolute potassium
excretion (p=0.01). Results of the histological study also indicated a significant decrease in
the vascular congestion, Bowman’s capsule space and oxidative stress in the group
(I/R+RO) in comparison with (I/R+NS).
Conclusion: Treatment with rosemary may be effective in the reduction of the functional
and histological effects of I/R.

Keywords

Rosmarinus officinalis

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References

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