Effect of Hydro-Alcoholic Extract of Teucrium Polium on Castor Oil-Induced Diarrhea in Male Rat

Mohammad Allahtavakoli; Rezwan Moradi; Sakineh Shamsi; Kianoosh Afsharmanesh

Zahedan Journal of Research in Medical Sciences

The Official Journal of Zahedan University of Medical Sciences

Current Issue All Issues In Press Articles Accepted Manuscripts Search

Journal Information Boards and Committees Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Contact Us Support Reviewer and AE Registration Form

APC

Authors Guide Submit Manuscript

Effect of Hydro-Alcoholic Extract of Teucrium Polium on Castor Oil-Induced Diarrhea in Male Rat

Author(s):

Mohammad Allahtavakoli^1,*,

Rezwan Moradi²,

Sakineh Shamsi²,

Kianoosh Afsharmanesh²

1Department of physiology, Physiology-Pharmacology Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

2Medical Student, Physiology-Pharmacology Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 15, issue 6; e92964

Published online:Oct 29, 2012

Article type:Research Article

Received:Aug 23, 2011

Accepted:Apr 26, 2012

How to Cite:Mohammad AllahtavakoliRezwan MoradiSakineh ShamsiKianoosh AfsharmaneshEffect of Hydro-Alcoholic Extract of Teucrium Polium on Castor Oil-Induced Diarrhea in Male Rat.Zahedan J Res Med Sci.15(6):e92964.

Abstract

Background : Diarrhea is one of the world's health problems as the most common causes of death in children. In this study, the effect of Teucrium Polium (TP) extract on diarrhea induced by castor oil has been studied.
Materials and Methods : 30 male rats were divided into five equal groups containing extract with doses of 100, 200 and 600 mg/kg diphenoxylate (5 mg/kg) and control group or vehicle (normal saline) groups. One hour after feeding the drugs or vehicle in the volume of 10 ml/kg, 2 ml of castor oil were fed to each animal through an oral-gastric catheter. Then excrements of animals were separately observed in the cages for 4 hours and their quality, frequency and stool weight were determined. Data analysis was performed using one-way ANOVA and Tukey post-test and p<0.05 was considered as significant.
Results : Diphenoxylate and 600 mg/kg dose of TP reduced the percentage of the weight loss of animals, their excretion frequency and defecation index (p< 0.001). The 600 mg/kg dose of TP decreased the fecal water content compared to the control group (p< 0.01).
Conclusion : Based on our data, essential oil of TP has an effect similar to diphenoxylate on the reduction of osmotic diarrhea symptoms and also reduces the volume of excreted water.

Keywords

Diarrhea

Teucrium Polium

Rat

Fulltext

The full text of this article is available on the PDF file.

References

1.
The References of this article are available on the PDF file.

comments