Effects of Chronic 5-Bromo-2-Deoxyuridine Administration on Spatial Memory in the Adult Rats

Mahmoud Hosseini; Abbas Mohammadi pour; Azadeh Feizpour; Vahid Ebrahimi

Zahedan Journal of Research in Medical Sciences

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Effects of Chronic 5-Bromo-2-Deoxyuridine Administration on Spatial Memory in the Adult Rats

Author(s):

Mahmoud Hosseini¹,

Abbas Mohammadi pour^2,*,

Azadeh Feizpour¹,

Vahid Ebrahimi²

1Department of Physiology, Mashhad University of Medical Sciences, Mashhad, Iran

2Department of Anatomy, Mashhad University of Medical Sciences, Mashhad, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 15, issue 5; e92977

Published online:Nov 18, 2012

Article type:Research Article

Received:Feb 21, 2012

Accepted:Oct 22, 2012

How to Cite:Mahmoud HosseiniAbbas Mohammadi pourAzadeh FeizpourVahid EbrahimiEffects of Chronic 5-Bromo-2-Deoxyuridine Administration on Spatial Memory in the Adult Rats.Zahedan J Res Med Sci.15(5):e92977.

Abstract

Background : 5-Bromo-2-deoxyuridine (BrdU) has been a principal marker for mitotic cells in studies of adult neurogenesis. The method consists of a pulse injection of BrdU into the intraperitoneal cavity followed by a variable survival time allowing for tracking the divided cells and their progeny. However, such exogenous markers may produce toxic effects. Aim of this study was determined the effects of Brdu on spatial memory in the adult rat.
Materials and Methods : 16 Wistar rats were used in this experimental study. The rats were randomly divided into 2 groups (N=8 in each group), as follows: control and Brdu (50 mg/kg). Brdu was administered intraperitoneally for 6 weeks and then animals were used for behavioral testing in the Morris water maze. The data were analyzed with repeated measure’s ANOVA.
Results : Our present findings show that there were no differences in the path length, escape latency and swim speed between control and Brdu-administrated groups.
Conclusion : This study show that Brdu (exogenic proliferation marker) did not has side effects on spatial memory in the adult rats.

Keywords

5-Bromo-2-deoxyuridine

Spatial memory

Rat

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