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Zahedan Journal of Research in Medical Sciences
The Official Journal of Zahedan University of Medical Sciences
e-ISSN 2383-2894
Outline
The Effect of Six Weeks-Voluntary Wheel Running on Brain Amyloid Beta (1-42) Levels of Diabetic Rats
Authors
1Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, University of Mazandaran, Babolsar, Iran
2Department of Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran
*Corresponding Author: Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, University of Mazandaran, Babolsar, Iran Email: [email protected]
Published online:Jan 07, 2012
Article type:Research Article
Received:May 05, 2019
Accepted:Dec 06, 2011
How to Cite:Fallah Mohammadi Z, Ebrahimzadeh M, hajizadeh moghaddam A. The Effect of Six Weeks-Voluntary Wheel Running on Brain Amyloid Beta (1-42) Levels of Diabetic Rats. Zahedan J Res Med Sci. 2013;15(5):e92984. doi:
Abstract
Background : Amyloid Beta (1-42) is derived from amyloid precursor protein and plays a critical role in AD pathogenesis. The purpose of this study was to investigate the effect of 6 weeks of voluntary wheel running on brain Amyloid beta (1-42) in the diabetic rats induced with alloxan.
Materials and Methods : 28 male rats weight 185±1 were assigned randomly to 4 groups (N=7): normal control (C), training (T), control-diabetic (CD) and diabetic-training (DT). Diabetes was induced with injecting Alloxan (120 mg/kg dissolved in saline) intraperitoneal.
Results : 6 weeks of voluntary wheel running decreased the cortex Aβ1-42 in T and DT groups. Aβ1-42 levels significantly decreased in the T and DT in compare with C and CD (p<0.001), respectively. Also Aβ1-42 levels significantly increased in the CD in compare with C (p<0.001).
Conclusion : voluntary exercise had positive effects on decreasing of Aβ1-42 levels during 6 weeks. Therefore it can be recommended as therapeutic strategy for diabetes.
Highlights
References
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Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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