The Effect of Six Weeks-Voluntary Wheel Running on Brain Amyloid Beta (1-42) Levels of Diabetic Rats

Zia  Fallah Mohammadi; Mojtaba Ebrahimzadeh; akbar hajizadeh moghaddam

Zahedan Journal of Research in Medical Sciences

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The Effect of Six Weeks-Voluntary Wheel Running on Brain Amyloid Beta (1-42) Levels of Diabetic Rats

Author(s):

Zia Fallah Mohammadi^1,*,

Mojtaba Ebrahimzadeh¹,

akbar hajizadeh moghaddam²

1Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, University of Mazandaran, Babolsar, Iran

2Department of Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 15, issue 5; e92984

Published online:Jan 07, 2012

Article type:Research Article

Received:May 05, 2019

Accepted:Dec 06, 2011

How to Cite:Zia Fallah MohammadiMojtaba Ebrahimzadehakbar hajizadeh moghaddamThe Effect of Six Weeks-Voluntary Wheel Running on Brain Amyloid Beta (1-42) Levels of Diabetic Rats.Zahedan J Res Med Sci.15(5):e92984.

Abstract

Background : Amyloid Beta (1-42) is derived from amyloid precursor protein and plays a critical role in AD pathogenesis. The purpose of this study was to investigate the effect of 6 weeks of voluntary wheel running on brain Amyloid beta (1-42) in the diabetic rats induced with alloxan.
Materials and Methods : 28 male rats weight 185±1 were assigned randomly to 4 groups (N=7): normal control (C), training (T), control-diabetic (CD) and diabetic-training (DT). Diabetes was induced with injecting Alloxan (120 mg/kg dissolved in saline) intraperitoneal.
Results : 6 weeks of voluntary wheel running decreased the cortex Aβ1-42 in T and DT groups. Aβ1-42 levels significantly decreased in the T and DT in compare with C and CD (p<0.001), respectively. Also Aβ1-42 levels significantly increased in the CD in compare with C (p<0.001).
Conclusion : voluntary exercise had positive effects on decreasing of Aβ1-42 levels during 6 weeks. Therefore it can be recommended as therapeutic strategy for diabetes.

Keywords

Aβ1-42

Voluntary wheel running

Rats

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References

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