Pituitary-Gonadal Axis Hormone and Semen Analysis in Narcotic Dependency

Raheleh Assaei; Hedayat Nazari; Naser Pajouhi; Saleh Zahedi-Asl

Zahedan Journal of Research in Medical Sciences

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Pituitary-Gonadal Axis Hormone and Semen Analysis in Narcotic Dependency

Author(s):

Raheleh Assaei^1,*,

Hedayat Nazari²,

Naser Pajouhi³,

Saleh Zahedi-Asl⁴

1Department of Physiology, Faculty of Medicine, Lorestan University of Medical Sciences, Khoramabad, Iran

2Department of Psychiatry, Faculty of Medicine, Lorestan University of Medical Sciences, Khoramabad, Iran

3Department of Physiology, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

4Endocrine Research Center, Shahid Beheshti University, Tehran, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 15, issue 4; e93008

Published online:Nov 05, 2012

Article type:Research Article

Received:Nov 02, 2011

Accepted:Jan 12, 2012

How to Cite:Raheleh AssaeiHedayat NazariNaser PajouhiSaleh Zahedi-AslPituitary-Gonadal Axis Hormone and Semen Analysis in Narcotic Dependency.Zahedan J Res Med Sci.15(4):e93008.

Abstract

Background : Drug abuse is associated with numerous complications including hormonal disorders of hypothalamic-pituitary-gonadal axis and spermatogenic disorders. We have compared the hormone concentration of pituitary-gonadal axis and the semen analysis in opioid-dependent and non-opioid-dependent men.
Materials and Methods : In this case-control study, serum concentration of pituitary- gonadal axis hormones and semen analysis in 48 opioid-dependent men as eligible to participate in the study were compared with those in 12 non-dependent men.
Results : Free testosterone concentration in all test groups was significantly less than that in control group. Furthermore, the concentration of Dihydrotestosterone (DHT) and Dehydroepiandrosterone Sulfate (DHEAS) in all test groups except those addicted to heroin was less than in those in control group. Concentrations of LH, FSH, prolactin, SHBG, progesterone and estradiol, normal and abnormal sperm count in test groups were significantly different from control group. However, in all test groups, sperm motility rate was less than control group. No significant relationship was found between the concentration of sex hormones and the status of sperms motility.
Conclusion : Chronic use of opioids will affect testosterone hormone and sperm, and it will cause hypogonadism and impairment of sperm motility.

Keywords

Addiction

Sex Hormones

Semen Analysis

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References

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