A Study on Oxidative Stress in Patients with Angina Pectoris Admitted to Coronary Care Unit

Mansour Karajibani; Farzaneh Montazerifar; Mohammad Hashemi; Ahmad Bolouri; Madhurima Dikshit

Zahedan Journal of Research in Medical Sciences

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A Study on Oxidative Stress in Patients with Angina Pectoris Admitted to Coronary Care Unit

Author(s):

Mansour Karajibani^1,*,

Farzaneh Montazerifar¹,

Mohammad Hashemi¹,

Ahmad Bolouri²,

Madhurima Dikshit³

1Department of Nutrition, Faculty of Medicine, Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

2Department of Cardiology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

3Department of Biochemistry, PUNE University Pune- 411007, India

Zahedan Journal of Research in Medical Sciences:Vol. 15, issue 3; e93055

Published online:Oct 30, 2012

Article type:Research Article

Received:Jul 20, 2011

Accepted:Sep 14, 2011

How to Cite:Mansour KarajibaniFarzaneh MontazerifarMohammad HashemiAhmad BolouriMadhurima DikshitA Study on Oxidative Stress in Patients with Angina Pectoris Admitted to Coronary Care Unit.Zahedan J Res Med Sci.15(3):e93055.

Abstract

Background : The oxidative stress causes biological damages in addition to the increase of cardiovascular system diseases such as angina pectoris. The present study aims to determine the oxidant and anti-oxidant (enzymatic and non-enzymatic) status in patients with angina pectoris.
Materials and Methods : In this descriptive-analytical study, 24 hospitalized patients with angina pectoris and 63 healthy people, as control group, were selected. Blood fats including cholesterol, triglyceride and HDL were determined through the enzymatic method and the LDL was determined using Friedewald formula. The heparinized blood was used to measure superoxide dismutase, glutathione peroxidase (GPx), and plasma to determine malondialdehyde (MDA) and vitamin C through spectrophotometeric method and total antioxidant capacity (TAC) through ferric reducing ability of plasma (FRAP). Vitamins A and E of serum were determined through the chromatography method in two groups and SPSS-11.5 software was used for statistical analysis. The degree of error in the tests was calculated as p<0.05.
Results : A significant difference was observed in blood fat contents as well as the oxidant and anti-oxidant (enzymatic and non-enzymatic) indices between the two groups (p<0.001). A positive and significant relationship was observed between superoxide dismutase and vitamin C, MDA and LDL. However, this relationship with HDL and TAC was negative and significant (p<0.05).
Conclusion : With respect to the significant decrease of anti-oxidants and TAC and the increase of lipid peroxidation as well as the relationship between the different indices, the oxidative stress caused anti-oxidants system suppression in patients.

Keywords

Oxidative stress

Lipid profile

Oxidant and antioxidants

Angina pectoris

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