Immunohistochemical Expression of Estrogen and Progesterone Receptors in Epulis Fissuratum

1Department of Oral & Maxillofacial Pathology, Dental Materials Research Center, Faculty of Dentistry, Babol University of Medical Sciences, Babol, Iran

2Department of Pathology, Cellular & Molecular Biology Research Center, Faculty of Dentistry, Babol University of Medical Sciences, Babol, Iran

3Dentist, Students' Research Center, Babol University of Medical Sciences, Babol, Iran

4Department of Biostatistic, Dental Materials Research Center, Babol University of Medical Sciences, Babol, Iran

5Department of Pathology, Babol University of Medical Sciences, Babol, Iran

6Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Babol University of Medical Sciences, Babol, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 15, issue 1; e93135

Published online:Oct 15, 2012

Article type:Research Article

Received:Nov 03, 2011

Accepted:Nov 23, 2011

How to Cite:Maryam SeyedmajidiShahryar ShafaeeMohammad Azhdarisoraya khafriSepideh SiadatiMohammad Mehdizadehet al.Immunohistochemical Expression of Estrogen and Progesterone Receptors in Epulis Fissuratum.Zahedan J Res Med Sci.15(1):e93135.

Abstract

Background : Epulis Fissuratum (Epulis Fissuratum (EF) or Denture Epulis or inflammatory fibrous hyperplasia) is a common hyperplastic tumor-like lesion with reactive nature, related to loose and ill-fitting, full or partial removable dentures and it is more common in women than men. For this reason, hormonal influences may also play role in its creation. The effect of steroid hormones especially sex hormones (Estrogen and progesterone) on oral mucosa is identified in some studies. In the present study, the distribution pattern and presence of estrogen and progesterone receptors in epithelial, stromal, endothelial and inflammatory cells in Epulis Fissuratum was investigated.
Materials and Methods : This cross-sectional study was carried out on 30 samples of paraffin blocks with Epulis Fissuratum diagnosis and 30 samples of normal mucosal tissues as a control group who have had surgery as a margin beside the above lesions and had been obtained from the oral and maxillofacial pathology departement of Babol Dental School since 2003 up to 2010. Intensity of staining and immunoreactivity were evaluated using subjective index and considering the positive control group (breast carcinoma).
Results : Epithelial, stromal, endothelial and inflammatory cells didn’t show reaction with monoclonal antibodies against estrogen and progesterone in none of the samples.
Conclusion : It seems that the hypothesis of the existence of estrogen and progesterone receptors in epulis fissuratum and normal oral mucosa is ruled out. The possibility of direct effect of estrogen and progesterone in occurring of epulis fissuratum is rejected.

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