Molecular Aspects of Glucose-6-Phosphate Dehydrogenase Deficiency in Iran

Ali Dehghanifard; Yousef Mortazavi; Najmaldin Saki; Majid Farshdusti-Hagh

Zahedan Journal of Research in Medical Sciences

The Official Journal of Zahedan University of Medical Sciences

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Molecular Aspects of Glucose-6-Phosphate Dehydrogenase Deficiency in Iran

Author(s):

Ali Dehghanifard¹,

Yousef Mortazavi^1,*,

Najmaldin Saki²,

Majid Farshdusti-Hagh³

1Department of Pathology, Zanjan University of Medical Sciences, Zanjan, Iran

2Department of Hematology, Thalassemia and Hemoglobinopathy Research Center, Jundi Shapur University of Medical Sciences, Ahvaz, Iran

3Department of Hematology, Division of Laboratory Hematology and Blood Banking, Tabriz University of Medical Sciences, Tabriz, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 14, issue 7; e93302

Published online:Jan 07, 2012

Article type:Review Article

Received:Aug 27, 2011

Accepted:Nov 16, 2011

How to Cite:Ali DehghanifardYousef MortazaviNajmaldin SakiMajid Farshdusti-HaghMolecular Aspects of Glucose-6-Phosphate Dehydrogenase Deficiency in Iran.Zahedan J Res Med Sci.14(7):e93302.

Abstract

Background: G6PD deficiency is the most common hereditary enzyme deficiency that affected more than 400 million people worldwide. This enzyme deficiency is caused by a spectrum of mutations in the gene encoding G6PD on chromosome X. Epidemiologically G6PD deficiency has been specially considered in Middle East countries including Iran, Oman and Saudi Arabia.
Materials and Methods: This study has reviewed more than 70 papers related to the epidemiological significance and various diagnostic strategies of G6PD deficiency from 1956 to 2010.
Results: The results showed a higher prevalence of Mediterranean variant followed by Chatham and Cosenza compared to other variants in Iran.
Conclusion: Accurate identification of G6PD deficiency variants in areas with high prevalence of this disease will help to screen patients and their families with risk level when faced with oxidant agents.

Keywords

Glucose-6-phosphate

dehydrogenase

Favism

Mediterranean Variant

Hemolytic anemia

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