Molecular Aspects of Glucose-6-Phosphate Dehydrogenase Deficiency in Iran


avatar Ali Dehghanifard 1 , avatar Yousef Mortazavi 1 , * , avatar Najmaldin Saki 2 , avatar Majid Farshdusti-Hagh 3

Department of Pathology, Zanjan University of Medical Sciences, Zanjan, Iran
Department of Hematology, Thalassemia and Hemoglobinopathy Research Center, Jundi Shapur University of Medical Sciences, Ahvaz, Iran
Department of Hematology, Division of Laboratory Hematology and Blood Banking, Tabriz University of Medical Sciences, Tabriz, Iran

how to cite: Dehghanifard A, Mortazavi Y, Saki N, Farshdusti-Hagh M. Molecular Aspects of Glucose-6-Phosphate Dehydrogenase Deficiency in Iran. Zahedan J Res Med Sci. 2012;14(7):e93302.


Background: G6PD deficiency is the most common hereditary enzyme deficiency that affected more than 400 million people worldwide. This enzyme deficiency is caused by a spectrum of mutations in the gene encoding G6PD on chromosome X. Epidemiologically G6PD deficiency has been specially considered in Middle East countries including Iran, Oman and Saudi Arabia.
Materials and Methods: This study has reviewed more than 70 papers related to the epidemiological significance and various diagnostic strategies of G6PD deficiency from 1956 to 2010.
Results: The results showed a higher prevalence of Mediterranean variant followed by Chatham and Cosenza compared to other variants in Iran.
Conclusion: Accurate identification of G6PD deficiency variants in areas with high prevalence of this disease will help to screen patients and their families with risk level when faced with oxidant agents.


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© 2012, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.