Pathological Evaluation of Phenobarbital and Atorvastatin Co-Administration on Kidney of Rat

Hossein  Najafzadeh; Hassan Morovvati; Babak Mohammadian; Mohammad Razijalali; S.Mahsa Poormoosavi

Zahedan Journal of Research in Medical Sciences

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Pathological Evaluation of Phenobarbital and Atorvastatin Co-Administration on Kidney of Rat

Author(s):

Hossein Najafzadeh^1,*,

Hassan Morovvati²,

Babak Mohammadian³,

Mohammad Razijalali³,

S.Mahsa Poormoosavi⁴

1Department of Pharmacology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran

2Department of Histology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran

3Department of Pathology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran

4Faculty of Veterinary Medicine, Shahid Chamran University,Ahvaz, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 14, issue 7; e93314

Published online:Dec 07, 2011

Article type:Research Article

Received:Aug 27, 2011

Accepted:Sep 29, 2011

How to Cite:Hossein NajafzadehHassan MorovvatiBabak MohammadianMohammad RazijalaliS.Mahsa PoormoosaviPathological Evaluation of Phenobarbital and Atorvastatin Co-Administration on Kidney of Rat.Zahedan J Res Med Sci.14(7):e93314.

Abstract

Background: Atorvastatin is a lipid-lowering drug used to treat hyperlipidemia. Phenobarbital is the inductor of cytochrome enzymes. This study examined the interfering effect of simultaneous consumption of these drugs on the biochemical and pathological changes in rat’s kidney.
Materials and Methods: Drugs were administered to 4 groups of Wistar rats (8 per group) for 15 days as follows: normal saline, atorvastatin, atorvastatin phenobarbital and phenobarbital alone. After anesthesia, blood was taken from the heart and serum was removed to measure myoglobin, creatinine, BUN, sodium, potassium and uric acid. After easy kill of rats, kidneys were removed and tissue sections were prepared through the conventional method of pathologic sections preparation and they were stained with Hematoxylin-Eosin, and pathological changes were examined by light microscopy.
Results: The simultaneous use of atorvastatin with phenobarbital significantly increased serum myoglobin of rats compared with control group. Pathological changes in the group receiving atorvastatin and phenobarbital simultaneously was observed with a greater intensity.
Conclusion: Phenobarbital can reduce renal toxicity of atorvastatin.

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