Association of Calcium-Sensing Receptor (CASR rs 1801725) with Colorectal Cancer

Akram Safaei; Elaham Arbabi-Aval; Maral Arkani; Khatun Karimi; Fatemeh Rostami; Mohsen Vahedi; Fateme Khorshidi; Mitra Iman; S. Reza Mohebi; Mohamad Vafae; S. Reza Fatemi; Mohammad Reza Zali

Zahedan Journal of Research in Medical Sciences

The Official Journal of Zahedan University of Medical Sciences

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Association of Calcium-Sensing Receptor (CASR rs 1801725) with Colorectal Cancer

Author(s):

Akram Safaei^1,*,

Elaham Arbabi-Aval¹,

Maral Arkani¹,

Khatun Karimi¹,

Fatemeh Rostami¹,

Mohsen Vahedi¹,

Fateme Khorshidi¹,

Mitra Iman¹,

S. Reza Mohebi¹,

Mohamad Vafae²,

S. Reza Fatemi¹,

Mohammad Reza Zali¹

1Gastroentrology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2Iranian Ostomy Society, Tehran, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 14, issue 7; e93315

Published online:Dec 25, 2011

Article type:Research Article

Received:Aug 20, 2011

Accepted:Oct 10, 2011

How to Cite:Akram SafaeiElaham Arbabi-AvalMaral ArkaniKhatun KarimiFatemeh RostamiMohsen VahediFateme KhorshidiMitra ImanS. Reza MohebiMohamad VafaeS. Reza FatemiMohammad Reza Zaliet al.Association of Calcium-Sensing Receptor (CASR rs 1801725) with Colorectal Cancer.Zahedan J Res Med Sci.14(7):e93315.

Abstract

Background: Calcium induces apoptosis in intestinal epithelial cells and subsequently prevents colorectal cancer through ion calcium receptor. Calcium-sensing receptor mutation reduces the expression of this receptor, and subsequently in reduces calcium transportation. Many studies have shown that Calcium-sensing receptor gene polymorphism may increase the risk of colorectal cancer. The purpose of this study is to assess the prevalence of calcium-sensing receptor polymorphisms (rs 1801725) in Iran society and to examine the role of this polymorphism in the increased risk of colorectal cancer (CRC).
Materials and Methods: The research was a case-control study. 105 patients with colorectal cancer and 105 controls were randomly studied using polymerase chain reaction and restriction fragment length polymorphism. χ2 test and software 16- SPSS were used for statistical analysis.
Results: In patient samples, the frequency of the genotypes TT, GT, GG in gene CASR rs 1801725 was respectively 64.8, 32.4, and 2.9 and the frequency of this polymorphism in control samples was respectively 51.2, 45.7, and 2.9. Frequency of allele G in patient samples was 0/48 and frequency of allele T was 0.25. In addition, Frequency of allele G in control samples was 0.74 and Frequency of allele T was calculated 0.19.
Conclusion: The results show that calcium-sensing receptor variant (1801725 rs) is not associated with increased risk of colorectal cancer.

Keywords

Rs 1801725

Colorectal cancer

Polymerase chain reaction

Restriction fragment length

polymorphism

Calcium-sensing receptor

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